金属有机课件Class No. 1.ppt

金属有机化学 --------- 金属参与的现代有机合成反应 王 磊 淮北师范大学 Definition of this course: C(H)-Metal bond is formed during/or after the reaction. Main Textbook: Prof. Ma Shengming (SIOC, AC, CN) 金属参与的现代有机合成反应 广东科技出版社, 第二版, 2003 在宣布仪式上，诺贝尔化学奖评委会主席佩尔·阿尔伯格将烯烃复分解反应描述为“交换舞伴的舞蹈”。他亲自走出讲台，邀请身边的皇家科学院教授和两位女工作人员一起在会场中央为大家表演烯烃复分解反应的含义。最初两位男士是一对舞伴，两位女士是一对舞伴，在“加催化剂”的喊声中，他们交叉换位，转换为两对男女舞伴，在场记者随即发出了笑声。 2011年7月24-28日，由国际纯粹与应用化学联合会（IUPAC）主办，中国科学院上海有机化学研究所和华东师范大学共同承办的第十六届导向有机合成的金属有机化学国际研讨会（16th IUPAC International Symposium on Organometallic Chemistry Directed Towards Organic Synthesis (OMCOS 16)在上海国际会议中心成功召开，麻生明院士和丁奎岭研究员共同担任大会主席 。  2010年化学诺贝尔奖得主Ei-ichi Negishi教授应邀做了题为Magical Power of d-Block Transition Metals—Pd-Catalyzed Cross-Coupling and Zr-Catalyzed Asymmetric Carboalumination of Alkenes (ZACA)的大会报告。 Ethylene + AlEt3? What is Ni? Ni is a transition metal. Here comes the story. (1912-2004) 1976: for his (H. C. Brown) studies on the structure of boranes illuminating problems of chemical bonding 1981 Fort Collins (Chair: L. S. Hegedus) The 1st International Symposium on Organometallic Chemistry Directed Towards Organic Synthesis 13th OMCOS: Geneva Organometallics at Lake Geneva -by H. Butensch?n Angew. Chem. Int. Ed. 2005, 44, 5556-5558. …A true fireworks display of palladium-catalyzed reactions was then presented by this year’s winner of the OMCOS award, S. Ma (Shanghai), who lectured on transition-metal- catayzed reactions of allenes. The carbometalation of allenes either leads to p-allyl complexes or to alkenyl metal compounds. A subsequent b-hydride elimination leads to new allenes. Ma also reported on multi-component reactions. A special bonus at the end of his impressive lecture was a rhodium-catalyzed synthesis of steroid 6 from bisallenes 5, which was carried out in 74% yield [Eq. (2)]. If the central C(CO2Me)2 unit in 5 is replaced by NTs (Ts = toluene-4- sulfonyl), diazasteroid 7 forms in 57% yield. 14th: Nara, Japan, August 2-6, 2007 15th: UK 16