LcS益生菌与预防乳腺癌.pptx

第三届环渤海营养学术会议LcS益生菌与预防乳腺癌石滨海 Ph.D养乐多(中国)投资有限公司 2013.11.01Today’s Topics什么是益生菌?干酪乳杆菌代田株(LcS)的有益健康作用LcS的预防乳腺癌研究What are probiotics?定义益生菌是活的微生物，当摄入足够数量时，对宿主起有益健康的作用。Probiotics are live microorganisms which, when administered in adequate amounts, confer a health benefit on the host.——粮农组织/世界卫生组织 FAO/WHO 2001益生菌食品乳酸菌饮品奶酪泡菜酸奶LcS对人体的健康作用干酪乳杆菌代田株 Lactobacillus casei strain Shirota(LcS) *代田稔博士在1933年首次成功分离并强化培养了对有益健康的LcS菌株， 1935年开始被应用于活性乳酸菌乳饮品。 活着到达肠道 平衡肠内菌群 改善排便 免疫调节 预防一些癌症及其复发代田稔博士健康作用干酪乳杆菌代田株动物实验人体试验Disease/conditionTreatment/doseEffect of LcSBowel movementp.o. LcS 109/kgNormalizationTumorsi.p., i.v. /100-250 ?gInhibitionImmune modulationi.p., i.v., i.pl., s.c., p.o. /100-250 ?gRegulation (augmentation)Metastasesi.v., i.l. /100-250 ?gInhibitionViral infectionp.o. /0.05%-containing diet (0.05% LcS)InhibitionBacterial infectioni.p., s.c. /100-250 ?g, p.o. / LcS 108-109InhibitionImmunoglobulin Ep.o. /0.05% LcSInhibition of IgE and modulation of cytokine productionAnaphylaxisi.p. /200 ?gInhibition of anaphylaxis and modulation of cytokine productionHypertensionp.o. /100 mg/kgInhibition of increased blood pressureType 1 diabetesp.o. /0.05% LcSInhibition of onsetAutoimmunep.o. /0.05% LcSInhibition of onsetArthritisp.o. /100-200 ?gInhibition of onsetInflammatory bowel diseasesp.o. /0.05% LcSInhibition of onsetColitis - associated cancerp.o. LcS 108Tumor suppresonDisease/conditionTreatment/doseEffect of LcSNormalization of intestinal florap.o. /LcS 107-1010, p.o. /LcS 109 (synbiotics)NormalizationConstipationp.o. /LcS 109-1010Decreases constipationIntestinal Putrefactionp.o. /LcS 1010InhibitionUterine/lung cancers.c., i.d., i.pl. Prolongation of survivalBladder cancerp.o. /LcS 1010Prevention of recurrence and risk reductionColon cancerp.o. /LcS 1010Prevention of recurrenceImmune modulationp.o. /LcS 1010Augmentation of NK activityHTLV-1-associated myelopathyp.o. /LcS 1010Improvement of spasticity and urinary symptomsShort bowel diseasep.o. /LcS 109, p.o. /LcS 109 (synbiotics)Im