表观遗传研究生一级_培训课件.ppt

* * * * * * * * * * * * * * * 单独的图片,在资料中 * 见ＰＷＳ文件夹,单独的图片,在资料中 * * 网上图,单独的图片,在资料中 * * 见ＢＷＳ文件夹及图集,单独的图片,在资料中 * * 位于染色体11p15.5，包含许多印记基因，其中IGF2父源表达， H19母源等位基因表达， Beckwith-Wiedemann综合征（BWS,过度生长综合征） * * * 教材图片 * * * * * 进行性肺病 * * * * 教材图片 * * 独立图片 * * * * 表观遗传异常与肿瘤发生 甲基化和去乙酰化药物治疗肿瘤 表观遗传学是建立在经典遗传学理论基础上，研究基因功能实现机制的遗传学分支学科 遗传学研究基因序列改变所致基因表达变化，如基因突变、基因杂合丢失和微卫星不稳定等；而表观遗传学则研究基于非基因序列改变所致基因表达变化，如DNA甲基化和染色质构象变化等 结束语 Reviews： Cell，2007：128 issue 4 Nature, 2007:vol447 issue 24 Web site : / / /labheads/allis/index.php http://www.babraham.ac.uk/chromatin/fraser.html FURTHER READING Yi Zhang: 张毅 Born: 1963, Sichuan BS: 1984 Agricultural University of China PhD: 1995 Florida State University at Tallahassee Postdoc: 1999 Robert Wood Johnson School of Medicine Asst. Prof. 1999-2004 University of North Carolina, Chapel Hill Associate Prof 2004-2005 UNC Professor 2005, HHMI2005 Graduate Student Pabon-Pena, L.M., Zhang, Y.,and Epstein, L. M. (1991). Newt satellite 2 transcripts self-cleave by using an extended hammerhead structure. Mol. Cell. Biol.11, 6109-6115. Coats, S. R., Zhang, Y.,and Epstein, L. M. (1994). Transcription of satellite 2 from the newt is driven by a snRNAtype of promoter. Nucleic Acids Res.22, 4697-4704. Zhang, Y.,and Epstein, L. M. (1996). Cloning and characterization of satellite 2 hammerheads from a diverse set of caudate amphibians. Gene172, 183-190. Postdoc Zhang, Y., Iratni, R., Erdjument-Bromage, H., Tempst, P., and Reinberg, D. (1997). Histonedeacetylasesand SAP18, a novel polypeptide, are components of a human Sin3 complex. Cell 89, 357-364. Zhang, Y., Sun, Z. W., Iratni, R., Erdjument-Bromage, H., Tempst, P., Hampsey, M., and Reinberg, D. (1998). SAP30, a novel protein conserved between human and yeast, is a component of a histonedeacetylasecomplex. Mol Cell1, 1021-1031. Zhang, Y., LeRoy, G., Seelig, H.-P., Lane, W., and Reinberg, D. (1998). The dermatomyositis-specific autoantigenMi2 is a component of a prote