High-ResolutionGenomicCopyNumberProfilingofGliobl.pptVIP

High-Resolution Genomic Copy Number Profiling of Glioblastoma Multiforme by Single Nucleotide Polymorphism DNA Microarray by Dong Yin, Seishi Ogawa, Norihiko Kawamata, Patrizia Tunici, Gaetano Finocchiaro, Marica Eoli, Christian Ruckert, Thien Huynh, Gentao Liu, Motohiro Kato, Masashi Sanada, Anna Jauch, Martin Dugas, Keith L. Black, and H. Phillip Koeffler Mol Cancer Res Volume 7(5):665-677 May 12, 2009 ?2009 by American Association for Cancer Research Representative SNP-Chip analysis and validation of GBM samples. Dong Yin et al. Mol Cancer Res 2009;7:665-677 ?2009 by American Association for Cancer Research Internal deletion of LRP1B in GBM. Representative deletions of the LRP1B gene are shown in the U118 GBM cell line and two GBM samples. Dong Yin et al. Mol Cancer Res 2009;7:665-677 ?2009 by American Association for Cancer Research Amplicon at chromosome 5p13.2. Dong Yin et al. Mol Cancer Res 2009;7:665-677 ?2009 by American Association for Cancer Research Chromosome 1p36 deletion in GBM. Four representative deletions as detected by SNP-Chip at 1p36 (top right). Dong Yin et al. Mol Cancer Res 2009;7:665-677 ?2009 by American Association for Cancer Research Chromosome 6q26-27 deletion in GBM. A. Dong Yin et al. Mol Cancer Res 2009;7:665-677 ?2009 by American Association for Cancer Research Dong Yin et al. Mol Cancer Res 2009;7:665-677 ?2009 by American Association for Cancer Research Major functional pathways dysregulated in GBM as detected by SNP-Chip. Dong Yin et al. Mol Cancer Res 2009;7:665-677 ?2009 by American Association for Cancer Research Representative SNP-Chip analysis and validation of GBM samples. A. 9p21.3 deletions: Four representative patterns of chromosome 9p21.3 deletions in GBM samples detected by SNP-Chip. Blue lines above each chromosome show total gene dosage; level 2 indicates diploid (2N) amount of DNA, which is normal. Green bars under each chromosome indicate the SNP sites showing heterozygosity in GBM samples. When heterozygosity