米索前列醇不同给药途径用于预防剖宫产术出血临床观察.docVIP

米索前列醇不同给药途径用于预防剖宫产术出血临床观察 　　doi：10.3969/j.issn.1007-614x.2014.12.28 　　摘 要 目的：探讨通过宫内给药、直肠给药、口服给药途径给予米索前列醇对预防剖宫产术出血产妇的临床疗效。方法：2013年1月-2014年1月收治分娩产妇666例，随机分成宫内给药组、直肠给药组和口服组，各222例。3组均在胎儿娩出后宫体注射催产素20μg，分别经采取宫内给药、直肠给药、口服给药途径给予米索前列醇400μg治疗。结果：宫内给药组术中出血量、产后2小时平均出血量、24小时平均出血量分别为（125.8±42.1）ml、（199.8±39.6）ml、（229.6±39.2）ml，直肠给药组术中出血量、产后2小时平均出血量、24小时平均出血量分别为（187.8±48.5）ml、（225.3±61.2）ml、（305.3±61.2）ml，口服组术中出血量、产后2小时平均出血量、24小时平均出血量分别为（131.2±40.9）ml、（205.8±42.1）ml、（258.9±55.1）ml；术中出血量方面，宫内给药组和口服组明显优于直肠给药组（P0.05）；24小时平均出血量方面，宫内给药组和口服组明显优于直肠给药组（P0.05），宫内给药组出血量略低于口服组；宫内给药组发生产后出血1例，出血发生率0.045%，直肠给药组发生产后出血4例，出血发生率1.8%，口服组发生产后出血2例，出血发生率0.045%，直肠给药组发生产后出血1例，出血发生率0.9%，3组比较差异有统计学意义（P0.05）。结论：宫内给予米索前列醇是预防剖宫产术出血的最佳给药途径。 　　关键词 剖宫产 米索前列醇 宫内给药 直肠给药 口服给药 　　The clinical observation of different routes of administration of misoprostol for the prevention of cesarean section hemorrhage 　　Wang Zhaofen 　　Department of Obstetrics and Gynecology，the Traditional Chinese Medicine Hospital of Yanshan Count，Wenshan State，Yunnan 663100 　　Abstract Objective：To investigate the clinical curative effect of intrauterine administration，rectal administration，oral administration of misoprostol for the prevention of cesarean section hemorrhage.Methods：666 cases of pregnant women were selected from January 2013 to January 2014.They were randomly divided into the intrauterine administration group，the rectal administration group and the oral group with 222 cases in each.Three groups were given 20μg uterine oxytocin injection after the delivery of fetus.Three groups were respectively given 400μg misoprostol by the intrauterine administration，rectal administration and oral administration.Results：In the intrauterine administration group，the amount of intraoperative bleeding，the average amount of bleeding of postpartum 2 hours，the average amount of bleeding of 24 hours were 125.8±42.1ml，199.8±39.6ml，229.6±39.2ml.In the rectal administration group，the amount of intraoperative bleeding，the average amount of bleed