ADA联合CEA、CA125、FT检测鉴别结核性与恶性胸腔积液的临床应用价值.docVIP

ADA联合CEA、CA125、FT检测鉴别结核性与恶性胸腔积液的临床应用价值 　　【摘要】 目的：探讨胸腔积液腺苷脱氨酶（ADA）、癌胚抗原（CEA）、糖类抗原125（CA125）和铁蛋白（FT）联合检测对良恶性积液的诊断价值。方法：选取48例肺癌患者与45例单纯性结核患者，ADA采用酶偶联监测法，化学发光免疫技术联合检测CEA、CA125、FT。结果：恶性积液组胸液CEA、CA125、FT和ADA分别为（58.13±16.17）ng/ml、（45.12±16.23）U/ml、（393.15±170.25）ng/ml、（18.23±8.91）U/L，结核组分别为（7.11±2.11 ）ng/ml、（12.12±3.45）U/ml、（122.32±70.15）ng/ml和（60.32±15.15）U/L，恶性积液组胸液CEA、CA125和FT明显高于结核组，结核组胸液ADA明显高于恶性积液组，差异有统计学意义（P0.05）。结论：联合检测胸腔积液中CEA、CA125、FT和ADA，对鉴别恶性积液和单纯结核性积液有临床诊断价值 。 　　【关键词】 胸腔积液； 癌胚抗原； 糖类抗原125； 铁蛋白； 腺苷脱氨酶 　　中图分类号 R561.3 文献标识码 B 文章编号 1674-6805（2014）3-0062-02 　　The Clinical Value of ADA joint CEA，CA125，FT Testing to Identify Tuberculous and Malignant Pleural Effusion/LI Hong-mei.//Chinese and Foreign Medical Research，2014，12（3）：62-63 　　【Abstract】 Objective：To investigate value to the diagnosis of benign and malignant effusion which in combination detection pleural effusion adenosine deaminase（ADA），carcinoembryonic antigen（CEA），carbohydrate antigen 125（CA125） and ferritin（FT）.Method：48 patients with lung cancer and 45 patients with simple TB were selected，ADA enzyme coupling monitoring method，chemiluminescence immune technology combined detection of CEA，CA125，FT.Result：The CEA，CA125，FT and ADA of cancerous effusion group respectively（58.13±16.17）ng/ml，（45.12±16.23）U/ml，（393.15±170.25）ng/ml and （18.23±8.91）U/L，the tuberculosis（TB） group respectively （7.11±2.11）ng/ml，（12.12±3.45）U/ml，（122.32 ±70.15）ng/ml and （60.32±15.15）U/L，the CEA，CA125 and FT of malignant effusion group were obviously higher than that of tuberculosis group，effusion ADA of TB group was obviously higher than that of malignant group，the difference was statistically significant（P0.05）.Conclusion：There has clinical diagnosis value which combined detection of pleural effusion in CEA，CA125，FT and ADA to differentiate malignant effusion and simple tuberculous effusion. 　　【Key words】 Pleural effusion； Carcinoembryonic antigen； Carbohydrate antigen 125； Ferritin； Adenosine deaminase 　　First-author’s