三阴乳腺癌的MR征象与病理对照研究.docVIP

三阴乳腺癌的MR征象与病理对照研究 　　【摘 要】目的：评价“三阴性”乳腺癌（即雌激素受体阴性、孕激素受体阴性、人类表皮生长因子受体2 阴性的癌）imaging findings of “triple-negative” breast cancer （ie， cancer that is estrogen receptor [ER] negative， progesterone receptor [PR] negative， and human epidermal growth factor receptor 2 [HER2] negative） and to compare them with those of breast cancers that are ER positive， PR positive，and HER2 negati的磁共振影像学表现，并与那些ER、PR阳性及HER2阴性的乳腺癌相对照。Materials and Method材料和方法：Institutional review board approval and informed consent were obtai回顾性分析184例经病理证实的三阴性乳癌（n = 66）或ER阳性/PR阳性/HER2阴性的乳腺癌（n = 118）The MR imaging findings in 176 randomly assigned women （mean age， 56 years； range， 29?87 years） with surgically confirmed triple-negative breast cancers （ n _ 59） or ER-positive/PR-positive/HER2-negative breast cancers （ n _ 117） were reviewed.妇女的磁共振图像。我们同时回顾分析了组织学类型、分级及生物学标记的病理报告MR imaging findings included tumor shape， margin， internal enhancement， and size， as well as intratumoral signal intensity that was stronger than or almost the same as that of water or vessels on T2-weighted MR images.我们womwn。Results： High histologic grade （ P _ .001）， unifocal lesion （ P _结果：三阴乳腺癌表现为高病理分级。在磁共振图像上，三阴乳腺癌通常表现为.012）， mass lesion type （ P _ .001）， smooth mass margin （ P _ .001）， rim enhancement （ P _ .001）， persistent en肿块类型（63/66， 95%），很少表现为非肿块类型。三阴乳腺癌更倾向于表现为具有光滑的边缘（26/66， 39%）、环形强化（53/66， 80%）和持续增强类型pattern （ P _ .005）， and very high intratumoral signal intensity on T2-weighted MR images （ P _ .002） were significantly associated with triple-negative breast canc类型类型 （28/66，42%）Very high intratumoral signal intensity on T2-weighted MR images was significantly associated with intratumoral necrosis （ P _ .00。 Conclusion： Several MR imaging features might be used for detecting triple-negative breast canc结论：我们的结果表明这些影像表现有助于诊断三阴乳腺癌。 　　【关键词】乳腺肿瘤；三阴；磁共振成像；病理学； 　　【中图分类号】R737.9 【文献标识码】A 【文章编号】1004-7484（2013）02-0303-02 　　三阴乳腺癌是最近两年被提出来专指雌激素受体（estrogen receptor，ER）、孕激素受体（progesterone receptor，PR）和人类表皮生长因子受体2亚型（human epidermal gro