奥扎格雷钠联合前列地尔治疗急性脑梗死疗效观察.docVIP

奥扎格雷钠联合前列地尔治疗急性脑梗死疗效观察 　　摘 要 目的：探讨奥扎格雷钠联合前列地尔治疗急性脑梗死临床疗效。方法：收治急性脑梗死患者100例，随机分成对照组和观察组各50例，对照组给予长春西汀20mg加入5%葡萄糖250ml或者生理盐水500ml中静滴，1次/日，血塞通注射液400mg加入5%葡萄糖注射液250ml或生理盐水250ml静滴，连续14天，并辅以拜阿斯匹灵、莫地平治疗。观察组给予奥扎格雷钠80mg加入生理盐水250ml，前列地尔10μg加入生理盐水250ml，静滴，1次/日，连续治疗10天。结果：经过治疗观察组基本治愈20例，显著进步17例，进步11例，无效2例，总有效率96.0%，对照组基本治愈10例，显著进步9例，进步9例，无效12例，总有效率76.0%，两组比较差异有统计学意义（P0.05）。结论：奥扎格雷钠联合前列地尔治疗急性脑梗死，二者取长补短，改善临床神经功能缺失，有效地缩小了梗死体积，疗效显著。 　　关键词 奥扎格雷 前列地尔（PGE1） 急性脑梗死 长春西汀 血塞通 　　Abstract Objective：To discuss the curative effect of sodium ozagrel combine with alprostadil treat acute cerebral infarction.Method：To collect 100 cases of acute cerebral infarction patients，from October 2012 to October 2013，randomly divided into control group and observation group，each group is 50 cases.The control group are given vinpocetine 20mg，vinpocetine add to 250ml 5% glucose or 500ml physiological saline，static drops，one time one day，Sanqi Panax Notoginseng injection 400mg add to 250ml 5% glucose injection or 500ml physiological saline，static drops，for 14 consecutive days，at the same time along with aspirin，mo horizon treatment.The observation group was given the sodium ozagrel 80mg，add to 250ml 0.9% NS，alprostadil 10ug add to 250mg 0.9% NS，static drops，one time one day，treatment for 10 consecutive days.Results：After treatmentin observation group，20 cases basic cure，17 casessignificant progress，11 cases progress，2 cases in vain，total effective rate is 96.0%.In control group，10 cases basic cure，9 cases significant progress，9 cases progress，12cases in vain，total effective rate is 76.0%.Comparing the two groups have significant difference（P0.05）.Conclusion：Sodium ozagrel combine with alprostadil treat acute cerebral infarction，the two complement each other，improvethe clinical nerve function loss，effectively reduces infarct volume，significant effect，is worthy to promote in clinical. 　　Key words Ozagrel；Alprostadil（PGE1）；Acute cerebral infarction；Vinpocetine；Sanqi Panax Notoginseng 　　急性脑梗死是脑血管内发生血栓、栓塞或其