- 1、本文档共56页,可阅读全部内容。
- 2、有哪些信誉好的足球投注网站(book118)网站文档一经付费(服务费),不意味着购买了该文档的版权,仅供个人/单位学习、研究之用,不得用于商业用途,未经授权,严禁复制、发行、汇编、翻译或者网络传播等,侵权必究。
- 3、本站所有内容均由合作方或网友上传,本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺!文档内容仅供研究参考,付费前请自行鉴别。如您付费,意味着您自己接受本站规则且自行承担风险,本站不退款、不进行额外附加服务;查看《如何避免下载的几个坑》。如果您已付费下载过本站文档,您可以点击 这里二次下载。
- 4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等,请点击“版权申诉”(推荐),也可以打举报电话:400-050-0827(电话支持时间:9:00-18:30)。
查看更多
HES 130/0.4 vs saline (CHEST study): safety and efficacy in the ICU? AKI, acute kidney injury; CHEST, Crystalloid versus Hydroxyethyl Starch Trial; HES, hydroxyethyl starch; ICU, intensive care unit; RIFLE, risk, injury, failure, loss and end-stage kidney injury; RRT, renal replacement therapy Myburgh et al. N Engl J Med 2012; 367: 1901–1911 Aim Evaluate safety of HES 130/0.42* vs saline in ICU patients Study design Multicentre, parallel group, blinded, randomised Comparison 6% HES 130/0.4 (N=3315) 0.9% saline (N=3336) Maximum daily dose: 50 mL/kg body-weight/day However, the mean daily dose was 526 mL, substantially max Patients ≥18 years Required fluid resuscitation in the ICU Heterogenous; patients with sepsis at baseline:HES 130/0.4 (N=979), saline (N=958) Primary endpoint Death at 90 days post-randomisation Secondary endpoints Incidence of AKI (5-category RIFLE criteria) Use of RRT Duration of RRT and mechanical ventilation Specified new organ failures Cause-specific mortality Within 90 days post-randomisation Trend to higher mortality with HES 130/0.4 vs saline in the ICU1 CI, confidence interval; HES, hydroxyethyl starch; RR, relative risk 1. Myburgh et al. N Engl J Med 2012; 367: 1901–1911; 2. Perner et al. N Engl J Med 2012; 367: 124–134 RR 1.06 (95% CI 0.96, 1.18) p=0.26 Rate of death was lower than expected due to patient exclusions, and substantially lower than that observed in similar studies (e.g. 6S study)1,2 However, a non-statistically significant increase in mortality at day 90 was observed with HES 130/0.4 compared with saline1 HES 130/0.4 Saline HES 130/0.4 significantly increases risk of RRT vs saline in the ICU Within 90 days post-randomisation. CI, confidence interval; HES, hydroxyethyl starch; RR, relative risk; RRT, renal replacement therapy Myburgh et al. N Engl J Med 2012; 367: 1901–1911 RR 1.21 (95% CI 1.00, 1.45) 21% p=0.04 Saline HES 130/0.4 Creatinine levels* revealed significantly higher risk of injury and failure in the H
您可能关注的文档
- ARUBA医院无线整体方案__培训课件.ppt
- CBP在脓毒症应用中的已知新知和探索__培训课件.ppt
- cellculture__培训课件.ppt
- CRRT的适应症及介入时机__培训课件.ppt
- CT在喉癌诊断中的价值分析__培训课件.ppt
- E8毒血症,脓毒血症休克的临床诊治路径1__培训课件.ppt
- EBV与细胞永生化__培训课件.ppt
- eewifi医院无线网络建设方案__培训课件.ppt
- ENT解剖咽__培训课件.ppt
- HgCEMS原理与方法__培训课件.ppt
- 2025年江西省贵溪市事业单位考试(中小学教师类D类)职业能力倾向测验试卷带答案.docx
- 2025年福建省石狮市职业能力倾向测验事业单位考试(中小学教师类D类)试题推荐.docx
- 2025年陕西省兴平市事业单位考试(中小学教师类D类)职业能力倾向测验试卷汇编.docx
- 2025年江西省乐平市职业能力倾向测验事业单位考试(中小学教师类D类)试题及参考答案1套.docx
- 2025年南通科技职业学院单招语文测试模拟题库完整版.docx
- 2025年南宁职业技术学院单招语文测试题库a4版.docx
- 2025年海南省琼海市事业单位公开招聘考试职业能力倾向测验(D类)(中小学教师类)真题及答案一套.docx
- 2025年湖南省沅江市事业单位考试职业能力倾向测验(中小学教师类D类)强化训练题库带答案.docx
- 2025年山东省肥城市事业单位考试(中小学教师类D类)职业能力倾向测验知识点试题含答案.docx
- 2025年浙江省桐乡市事业单位考试(中小学教师类D类)职业能力倾向测验重点难点精练试题新版.docx
文档评论(0)