- 1、本文档共56页,可阅读全部内容。
- 2、有哪些信誉好的足球投注网站(book118)网站文档一经付费(服务费),不意味着购买了该文档的版权,仅供个人/单位学习、研究之用,不得用于商业用途,未经授权,严禁复制、发行、汇编、翻译或者网络传播等,侵权必究。
- 3、本站所有内容均由合作方或网友上传,本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺!文档内容仅供研究参考,付费前请自行鉴别。如您付费,意味着您自己接受本站规则且自行承担风险,本站不退款、不进行额外附加服务;查看《如何避免下载的几个坑》。如果您已付费下载过本站文档,您可以点击 这里二次下载。
- 4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等,请点击“版权申诉”(推荐),也可以打举报电话:400-050-0827(电话支持时间:9:00-18:30)。
查看更多
HES 130/0.4 vs saline (CHEST study): safety and efficacy in the ICU? AKI, acute kidney injury; CHEST, Crystalloid versus Hydroxyethyl Starch Trial; HES, hydroxyethyl starch; ICU, intensive care unit; RIFLE, risk, injury, failure, loss and end-stage kidney injury; RRT, renal replacement therapy Myburgh et al. N Engl J Med 2012; 367: 1901–1911 Aim Evaluate safety of HES 130/0.42* vs saline in ICU patients Study design Multicentre, parallel group, blinded, randomised Comparison 6% HES 130/0.4 (N=3315) 0.9% saline (N=3336) Maximum daily dose: 50 mL/kg body-weight/day However, the mean daily dose was 526 mL, substantially max Patients ≥18 years Required fluid resuscitation in the ICU Heterogenous; patients with sepsis at baseline:HES 130/0.4 (N=979), saline (N=958) Primary endpoint Death at 90 days post-randomisation Secondary endpoints Incidence of AKI (5-category RIFLE criteria) Use of RRT Duration of RRT and mechanical ventilation Specified new organ failures Cause-specific mortality Within 90 days post-randomisation Trend to higher mortality with HES 130/0.4 vs saline in the ICU1 CI, confidence interval; HES, hydroxyethyl starch; RR, relative risk 1. Myburgh et al. N Engl J Med 2012; 367: 1901–1911; 2. Perner et al. N Engl J Med 2012; 367: 124–134 RR 1.06 (95% CI 0.96, 1.18) p=0.26 Rate of death was lower than expected due to patient exclusions, and substantially lower than that observed in similar studies (e.g. 6S study)1,2 However, a non-statistically significant increase in mortality at day 90 was observed with HES 130/0.4 compared with saline1 HES 130/0.4 Saline HES 130/0.4 significantly increases risk of RRT vs saline in the ICU Within 90 days post-randomisation. CI, confidence interval; HES, hydroxyethyl starch; RR, relative risk; RRT, renal replacement therapy Myburgh et al. N Engl J Med 2012; 367: 1901–1911 RR 1.21 (95% CI 1.00, 1.45) 21% p=0.04 Saline HES 130/0.4 Creatinine levels* revealed significantly higher risk of injury and failure in the H
您可能关注的文档
最近下载
- vitamix-料理机食谱其他--29种.pdf
- 口腔正畸学第九章 常见错牙合畸形矫治-深覆牙合【29页】.pptx VIP
- 河南省 唐河县志.pdf
- 国有企业总经理办公会议事规则.pdf VIP
- 学校热泵热水工程方案(3篇).docx
- 2025年行政职业能力测试题库 .pdf VIP
- 9.2.2 用坐标表示平移 课件(共51张PPT)数学人教版七年级下册.pptx VIP
- 住房项目设计采购施工总承包工程(EPC)投标方案技术标.docx
- J B-T 8521.1-2007 编织吊索 安全性 第一部分:一般用途合成纤维扁平吊装带.pdf VIP
- 《基本分析与技术分析相结合的A股投资策略案例报告》6200字.doc
文档评论(0)