不同体重多囊卵巢综合征患者内分泌和代谢相关指标分析.doc

不同体重多囊卵巢综合征患者内分泌和代谢相关指标分析【摘要】目的：比较不同体重多囊卵巢综合征(polycystic ovarian syndrome，PCOS)患者内分泌和代谢特点差异，为早期、科学合理诊治提供理论依据。方法：选取2007年11月～2009年9月我院就诊育龄期PCOS患者92例，按体重指数(BMI)分为23 kg/m2 组(体重正常组)45例，23～25 kg/m2组21例，≥25 kg/m2组(肥胖组)26例，检测各组PCOS患者的血清基础性激素、血糖及胰岛素水平，并对3组的内分泌和代谢相关指标进行对比。结果：PCOS患者BMI 23～25 kg/m2组和≥25 kg/m2组睾酮(T)水平、胰岛素(INS)水平及胰岛素抵抗指数(IR)发生率均较BMI23 kg/m2组高，差异有统计学意义(P0.05～0.01);BMI≥25 kg/m2组INS水平较BMI 23～25 kg/m2 组高，差异有统计学意义(P0.01);BMI≥25 kg/m2组糖脂异常发生率较BMI23 kg/m2组高，差异有统计学意义(P0.01)。结论：不同体重PCOS的临床表现和生化特征存在差异，肥胖PCOS患者存在更严重的内分泌紊乱。 　　【关键词】 多囊卵巢综合征 ;胰岛素抵抗; 肥胖 　　[ABSTRACT] Objective： To compare the characteristics of endocrine and metabolic of the different weight women with polycystic ovary syndrome(PCOS)for the purpose of providing theoretical basis for early diagnosis and reasonable treatment PCOS.Methods： 92 patients in childbearing age with PCOS from November 2007 and September 2009 at our hospital were selected.PCOS patients were divided into three groups according to the body mass index(BMI) as BMI23,23≤BMI25 and BMI≥25.The level of based serum hormone， glucose and insulin were detected and the indexes of endocrine and metabolic in the three groups were compared. Results： Testosterone in PCOS patients both in 23≤BMI25 group and BMI≥25 group were higher than that in BMI23 group (P0.05). Insulin and the prevalence of insulin resistance of PCOS patients in作者：辛俊英　　作者单位：河北省承德市中医院妇产科，河北 承德 　　23≤BMI25 group and BMI≥25 group were higher than those in BMI23 group(P0.01).The prevalence of dyslipidemia of PCOS patients in BMI≥25 group were higher than that in 23≤BMI25 group(P0.01).Conclusions：The clinical manifestation and biochemical characteristics of PCOS for populations in different regions are different. PCOS patients with obesity have more serious endocrine disorders. 　　[KEY WORDS] Polycystic ovary syndrome; Insulin resistance; Obesity 　　多囊卵巢综合征(polycystic ovarian syndrome，PCOS)是神经、内分泌系统及代谢调控失衡引起的疾病，是涉及神经内分泌、代谢等诸多因素的终身性疾病[1]。目前PCOS病因和发病机制仍不明确，胰岛素抵抗(insulin resistance，IR)和高雄激素血症(hype