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Stealth sensors: real-time monitoring of the cell cycle??Review ArticleTARGETS The cell cycle is of key importance to many areas of drug discovery. On the one hand this fundamental process provides the opportunity to discover new targets for anticancer agents and improved chemotherapeutics, but on the other hand drugs and targets in other therapeutic areas must be tested for undesirable effects on the cell cycle. Historically, a wide range of techniques have been developed to study the cell cycle both as a global biochemical process and at the molecular level. This article reviews a range of methods for analysis of the cell cycle and introduces a novel class of dynamic stealth sensors based on expression, localization and degradation of green fluorescent protein under the control of key components of cell cycle regulation. These sensors allow the precise status of the cell cycle to be determined in live cells by fluorescence imaging without perturbing cell cycle progression. Article Outline 1. What are the applications of CCPMs? 2. How do CCPMs work? 3. What distinguishes CCPMs from other available methods of cell cycle analysis? 3.1. Methods for measuring cell proliferation 3.2. Methods for analyzing cell cycle distribution 3.3. Measuring cell cycle progression 3.4. Real-time analysis of cell cycle events 4. What are the strengths and weaknesses of CCPMs? 5. Who are considered to be the major competitors in the field? 6. What partnerships do you have to date? Acknowledgements References Swiss Air Force fighter jet F-5E as a research platform for cell culture experiments in microgravity??Original Research ArticleActa radar technology to reinforced concrete structures: a case study??Original Research ArticleNDT E International Aviation fuel JP-5 and biodiesel on a diesel engine??Original Research ArticleFuel, Electrical properties of Titans surface from Cassini RADAR scatterometer measurements??Original Research ArticleIcarus Modeling the