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[新抗栓治疗概况及展望[新抗栓治疗概况及展望[新抗栓治疗概况及展望
抗栓治疗概况及展望
中山大学附属第一医院心内科
胡承恒
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Virkow’s Triad (1847)
内皮损伤
血流改变
高凝
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Fibrin
Platelets
RBCs
White Thrombus
Fibrin
Platelets
RBCs
Coagulation (red) Thrombus
高流速 低流速
动脉血栓和静脉血栓
RBCs, red blood cells.
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血小板激活通道
血小板激活
纤维蛋白原
纤维蛋白结合位点
ADP
凝血酶
血小板
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血小板参与启动血栓形成过程
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fondaparinux
抗栓药物及作用机制
VKA
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血小板活化
血栓
损伤
血小板聚集
凝血酶生成
凝血酶活化
Aspirin
Ticlopidine
Clopidogrel
IIb/IIIa blockers
Heparin
LMWH
Pentasaccharide
Warfarin
LMWH
Heparin
Antithrombins
动脉血栓栓塞的治疗
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