[第4章免疫球蛋白1.ppt

第四章 免疫球蛋白 Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile 5.2.0.0. Copyright 2004-2011 Aspose Pty Ltd. Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile 5.2.0.0. Copyright 2004-2011 Aspose Pty Ltd. 免疫球蛋白 内容提要 概述 免疫球蛋白的结构 抗体的异质性 五类免疫球蛋白的生物学特性 免疫球蛋白基因及抗体的多样性 人工制备抗体 Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile 5.2.0.0. Copyright 2004-2011 Aspose Pty Ltd. Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile 5.2.0.0. Copyright 2004-2011 Aspose Pty Ltd. 免疫球蛋白和抗体概念 抗体 B细胞识别抗原后增殖分化为浆细胞所产生的糖蛋白，主要存在于血清等体液中。 Ag B 浆细胞 抗体 活化、增殖、分化 Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile 5.2.0.0. Copyright 2004-2011 Aspose Pty Ltd. Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile 5.2.0.0. Copyright 2004-2011 Aspose Pty Ltd. 免疫球蛋白和抗体概念 免疫球蛋白 具有抗体活性或结构与抗体相似的球蛋白统一命名为免疫球蛋白 分泌型免疫球蛋白(sIg)→抗体 存在于体液（血清、组织液、外分泌液）中。 膜型免疫球蛋白(mIg) 存在于B细胞膜表面, 即BCR。比sIg多一个跨膜区和一个胞浆区。 Ab=Ig,Ig≠Ab； Ab是功能描述，Ig是化学结构描述。 Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile 5.2.0.0. Copyright 2004-2011 Aspose Pty Ltd. Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile 5.2.0.0. Copyright 2004-2011 Aspose Pty Ltd. Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile 5.2.0.0. Copyright 2004-2011 Aspose Pty Ltd. Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile 5.2.0.0. Copyright 2004-2011 Aspose Pty Ltd. 免疫球蛋白的基本结构 重链和轻链 可变区和恒定区 铰链区 功能区 其它成分 水解片段 Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile 5.2.0.0. Copyright 2004-2011 Aspose Pty Ltd. Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile 5.2.0.0. Copyright 2004-2011 Aspose Pty Ltd. 免疫球蛋白的基本结构 Ig是由两条相同的重链和两条相同的轻链通过二硫键连接而成的4肽链分子，称为Ig的基本结构。 Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile 5.2.0.0. Copyright 2004-2011 Aspose Pty Ltd. Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Pro