[药剂学实验.doc

药剂学专业实验论文 学 校：清华大学 学 院: 化 工 学 院 年 级: 药物制剂 学 号: 。。。。。。。。。。。 姓 名。。。。。。。。。。。。。。 同 组 者: 。。。。。。。。。。。 复方双黄连胶囊的研制 摘要：目的: 通过复方双黄连胶囊制备的整个过程，掌握常用的中药提取的方法和原理；掌握湿法制粒、制胶囊的过程和技术；掌握胶囊剂项下的质量检查项目和检查方法及药效学研究方法；掌握旋转蒸发仪、溶出仪、崩解仪、及紫外分光光度计的使用。利用统计法观察双黄连对二甲苯所致小鼠耳肿胀的作用。方法： 水煎法提取金银花、连翘、黄芩药材中的有效成分；湿法制粒制胶囊；用分析天平测定胶囊的质量差异、用崩解仪测定崩解时限、用紫外分光光度仪进行黄芩苷含量测定、薄层色谱法进行胶囊剂的鉴别；用小鼠耳肿胀模型进行双黄连胶囊的药效学研究。结果：从原料药制得了胶囊，对胶囊进行了鉴别、质量检查和含量测定及药效学研究，基本符合规定。结论:通过原药材提取，制得胶囊，并进行各项检查和研究，掌握了全套的药物提取、制剂、检查方法，锻炼了良好的实验设计分析和实验技能。 关键词：复方双黄连、胶囊、回流提取、湿法制粒、鉴别、检查、含量测定、药效学 Preparation of compound Shuanghuanglian capsules Abstract：Purpuses To master the commonly used extraction methods and principles of traditional Chinese medicine,to master the usage of Rotary evaporator and Vacuum drier ;to master the methods and principles of wet granulation; to master the methods for the examination of the quality of the capsules and pharmacodynamic research methods; to master Thin Layer Chromatography technique and the use of Disintegration apparatus and Uv spect rophotometry..Methods Chinese medicine –Jinyinhua、Lianqiao and Huangqing were extracted using the method of decocting.The capsules were prepared by wet granulating.and identified using the method of TLC identification.The disintegration time of the capsules was examed using Disintegration apparatus. The content of Huangqingan in compound Shuanghuanglian capsules was determined using the method of dual wavelength spectrophotometry. The research of pharmacodynamics of compound Shuanghuanglian capsules was conducted using the model of mouse ear inflammation. Results We got thirty compound Shuanghuanglian capsules that conform to the quality criterions and have anti-inflammatory effect.Conclusion We can prepare compound Shuanghuanglian capsules that conform to the quality criterion with the methods above.These capsules have anti-inflammatory effect ,besides,the greater dose ,the b