AR磷酸化修饰AR酸化修饰.doc

Post-translational modifications:? Sumoylated on Lys-386 (major) and Lys-520. Ubiquitinated. Deubiquitinated by USP26. Lys-6 and Lys-27-linked polyubiquitination by RNF6 modulates AR transcriptional activity and specificity1 Phosphorylated in prostate cancer cells in response to several growth factors including EGF. Phosphorylation is induced by c-Src kinase (CSK). Tyr-534 is one of the major phosphorylation sites and an increase in phosphorylation and Src kinase activity is associated with prostate cancer progression. Phosphorylation by TNK2 enhances the DNA-binding and transcriptional activity and may be responsible for androgen-independent progression of prostate cancer. Phosphorylation at Ser-81 by CDK9 regulates AR promoter selectivity and cell growth. Phosphorylation by PAK6 leads to AR-mediated transcription inhibition1 Palmitoylated by ZDHHC7 and ZDHHC21. Palmitoylation is required for plasma membrane targeting and for rapid intracellular signaling via ERK and AKT kinases and cAMP generation1 Ubiquitination2?at Lys845, Lys847 Life Sciences Research Contact Us 窗体顶端 窗体底端 Challenges Solutions Knowledge Latest Home ? Knowledge ? Transcription_Androgen Receptor nuclear signaling KNOWLEDGE Pathway Maps Publications Webinars Training Quick Start Videos Pathway maps Transcription_Androgen Receptor nuclear signaling Object List (links open in MetaCore): IGF-1,?Kallikrein 3 (PSA),?p300,?p21,?IL-6 receptor,?EGFR,?Dsh,?Pyk2(FAK2),?EGF,?MEK1(MAP2K1),?c-Raf-1,?IL-6,NCOA2 (GRIP1/TIF2),?Androgen receptor,?SOS,?H-Ras,?5-alpha-Dihydrotestosterone cytoplasm,?VIL2 (ezrin),Testosterone,?GRB2,?Hic-5,?TGF-beta receptor type II,?PAK6,?RAD9,?TGF-beta receptor type I,?STAT3,?S5AR2,Galpha(q)-specific frizzled GPCRs,?SMAD3,?1.3.99.5,?N-CoR,?Cyclin D1,?SCAP,?S5AR1,?WNT,?TGF-beta 1,?GSK3 beta,?IGF-1 receptor,?ERK2 (MAPK1),?PKA-cat (cAMP-dependent),?Beta-catenin,?AKT1,?Shc,?MMP-2,?NCOA1 (SRC1) Description Androgen Receptor nuclear signaling Androgen is the active metabolic product,?