Buchwald-Hartwig..doc

Buchwald-Hartwig Cross Coupling Reaction Palladium-catalyzed synthesis of aryl amines. Starting materials are aryl halides or pseudohalides (for example triflates) and primary or secondary amines. The synthesis of aryl ethers and especially diaryl ethers has recently received much attention as an alternative to the Ullmann Ether Synthesis. Newer catalysts and methods offer a broad spectrum of interesting conversions. Mechanism of the Buchwald-Hartwig Coupling ? Recent Literature [(CyPF-tBu)PdCl2]: An Air-Stable, One-Component, Highly Efficient Catalyst for Amination of Heteroaryl and Aryl HalidesQ. Sheng, J. F. Hartwig, Org. Lett., 2008, 10, 4109-4112. A Multiligand Based Pd Catalyst for C-N Cross-Coupling ReactionsB. P. Fors, S. L. Buchwald, J. Am. Chem. Soc., 2010, 132, 15914-15917. Palladium-Catalyzed Coupling of Ammonia with Aryl Chlorides, Bromides, Iodides, and Sulfonates: A General Method for the Preparation of Primary ArylaminesG. D. Vo, J. F. Hartwig, J. Am. Chem. Soc., 2009, 131, 11049-11061. (IPr)Pd(acac)Cl: An Easily Synthesized, Efficient, and Versatile Precatalyst for C-N and C-C Bond FormationN. Marion, E. C. Ecarnot, O. Navarro, D. Amoroso, A. Bell, S. P. Nolan, J. Org. Chem., 2006, 71, 3816-3821. Synthesis of Bulky and Electron-Rich MOP-type Ligands and Their Applications in Palladium-Catalyzed C-N Bond FormationX. Xie, T. Y. Zhang, Z. Zhang, J. Org. Chem., 2006, 71, 6522-6529. Triazole-Based Monophosphine Ligands for Palladium-Catalyzed Cross-Coupling Reactions of Aryl ChloridesQ. Dai, W. Gao, D. Liu, L. M. Kapes, X. Zhang, J. Org. Chem., 2006, 71, 3928-3934. Bulky Alkylphosphines with Neopentyl Substituents as Ligands in the Amination of Aryl Bromides and ChloridesL. L. Hill, L. R. Moore, R. Huang, R. Craciun, A. J. Vincent, D. A. Dixon, J. Chou, C. J. Woltermann, K. H. Shaughnessy, J. Org. Chem., 2006, 71, 4951-4955. Water-Mediated Catalyst Preactivation: An Efficient Protocol for C-N Cross-Coupling ReactionsB. P. Fors, P. K