组蛋白的甲基化 组蛋白甲基化.doc

组蛋白的甲基化 组蛋白甲基化 SnapShot: Histone LysineMethylase Complexes Man Mohan, Hans-Martin Herz, and Ali Shilatifard Stowers Institute for Medical Research, Kansas City, MO 64110, USA Yeast(S. cerevisiae. cerevisiae) Biochemical/ biological properties SETDB1 CAF1 HeterochromatinHP1 formation/silencing Methylase Substrate Drosophila Mammals KMT1 H3K9 Not detected Su(var)3-9Su(var)3G9a SUV39H1/2 SETDB1 ATF7IP KMT1A/B KMT1A/B KMT1C KMT1E G9A GLP KMT1C/D Cps40 KMT2 H3K4 Cps60 Cps25 Set1 Cps50 Cps35 Cps30 Dpy30 Ash2 Trx Dpy30 Rbbp5 Set1 Mnn1 WdsRbbp5 Wdr82 Wds Ash2 Cxxc1 ASH2 DPY30 MLL1/2 RBBP5 MEN1 WDR5 CXXC1 ASH2 SET1A/B DPY30 RBBP5 Active transcription;homeotic gene expression; nuclearhormone receptorsignaling KMT2A/B HcfLpt Ash2 Dpy30 UtxTrr Rbbp5 Pa1 PtipWds KMT2F/G KMT2A/B WDR82 WDR5 HCF1 ASH2 DPY30 UTX PA1 MLL3/4 RBBP5 PTIP WDR5 NCOA6 KMT2F/G KMT2C/D ySet1/COMPASS Set2 KMT3 H3K36 CTD RNA Pol II CTD RNA Pol II Drosophila COMPASS Family Set2 Mes-4 KMT2C/D Mammalian COMPASS Family SET2 CTD RNA Pol II WHSC1 Active transcription KMT3A KMT3A KMT3A AF10 AF9 DOT1 TRRAP AF17 ENL KMT3B KMT4 H3K79 Dot1Grappa Active transcription; cell-cycle regulation;Wnt signaling KMT4 KMT4 KMT4 DotCom KMT5 H4K20 Not detected PR-Set7 Su(var)4-20 PR-Set7 SUV4-20H1/H2 Transcriptionalrepression; DNAdamage response KMT5A KMT5B/C KMT5A KMT5B/C Su(z)12 Nurf55 KMT6 H3K27 Not detected Jing Pcl Jarid2 E(z) Esc/Escl RBBP4/RBBP7AEBP2 SUZ12 EZH1/EZH2 EED JARID2 Polycomb silencing;X chromosomeinactivation; cellfate determination PHF1 MTF2 PHF19 KMT6 KMT6 S-adenosyl-L-methionineS-adenosyl-L-methionineS-adenosyl-L-methionine CH3 CH3 CH3 CH3 CH3 CH3 KMT KMT KMT Monomethylation (me)Dimethylation (me2)Trimethylation (me3) 498 Cell 149, April 13, 2012 ?012 Elsevier Inc. DOI 10.1016/j.cell.2012.03.025See online version for legend and references. SnapShot: Histone Lysine Methylase Complexes Man Mohan, Hans-Martin Herz, and Ali Shilatifard Stowers Institute for Medical Research, Kansas City, MO 641