从错误端生成肽(化学翻译).doc

从错误端生成肽(化学翻译) 导读：就爱阅读网友为您分享以下“从错误端生成肽(化学翻译)”的资讯，希望对您有所帮助，感谢您对92的支持! Building peptides from the wrong end 06 May 2008 UK chemists have cracked a long-standing problem in peptide synthesis that has prevented amino acid chains being grown from both ends. The insight could open up efficient ways to make peptide-based drugs. Lawrence Harwood and colleagues at the University of Reading say they have discovered a way to extend peptides from the carboxylic acid end without scrambling the stereochemistry - solving a problem that has stumped chemists for decades. The Reading team has now won a ￡63,000 grant for commercialisation of the technique, to license to companies working in the rapidly growing market of peptide-based drugs. All peptides have a carbon terminus at one end, and a nitrogen terminus at the other. But because of issues with stereochemistry, chemists are currently limited to extending peptides from the nitrogen end. quot;This is such a profound problem that the impossibility of synthesising peptides from the acid terminus has become dogma in the fieldquot; - Lawrence Harwood #39;Conventional peptide synthesis is always carri