《2010年全国中西医结合防治心脑血管疾病.docVIP

2010年全国中西医结合防治心脑血管疾病学术大会论文 血栓（thrombus）与基因表达障碍的关系 李建民 南开大学生命科学院教授 （天津市南开区卫津路94号南开大学 E-mail: jiali 97@126.com） 摘要： 除直接构成血栓的纤维蛋白、红细胞、白细胞、血小板之外，引起血栓形成的基础原因是“三高”（高脂、高糖、高血压），而造成“三高”的根本原因是基因表达障碍导致的“三低”（激素浓度低、酶浓度低、抗体浓度低）。更是代谢综合征的病因。 基因表达过程需两性物质核酸和蛋白质参与，能影响两性物质的最基础物质是酸碱变化。随着人体逐年老化，体内调节缓冲酸碱的能力已衰退，加上不良生活方式、环境污染，造成人体偏酸是无可争议的。实验证实：pH 值下降与基因表达产物蛋白质的生物合成浓度是成正相关。本文作者已发表论文《酸驱动代谢综合征（MS）的分子逻辑和实验探讨》（2005年北京人民大会堂中国名医论坛获优秀论文一等奖）。 Abstract Relationship between thrombus and hindrance of gene expression professor Li jian min Collge of life sciences NanKai Vnivercity (Tianjin 300071, P.R.CHINA) The pathogenic reason for the formation of thrombus is the “There Highs” (hyperlipoproteinemia, hyperglycemia, hypertension) The basic reason for the “Three Highs” is the hindrance of gene expression which leads to the “Three Lows” (low concentration of hormones, low concentration of enzymes, low concentration of antibodies) Two amphiphilic substances—nucleic acid and protein are involved in gene expression and are basically affected by any changes of the pH value. As the ageing of the human body, the capability of regulating the acid –base equilibrium declines in vivo. Furthermore maladjusted life-style and environmental pollution cause the human body to spontaneously accumulates acidic substances, promoting it to become slightly acidic. This reality is now with no dispute. Experimental results confirmed that as the pH value in the body decreased, the amount of proteins synthesized by gene expression also decreased。This result is of positive correlation. The author of this paper shall discuss, “ Molecular logic and experimental results of acid as a promoter in metabolic syndrome” (won the first grade prize of excellent thesis at the “Well Known Chinese Doctors Forum” in Beijing at the Great Hall of the People,2005. 引 言 唯物辩证法认为：生命体与其外界环境是辩证统一的；祖国医学更是遵循“天人合一”的准则。近期大量科学研究结果：外界因素可以影响基因乃至基因表达，这就打破了基因不变的封闭式旧观念。突破了障碍，使人们向更深层次基因分子水平去探讨疾病发生的病因和治疗疾病的药理。从生命的本质去解决有关问题，大道至简，开辟中医药走向现代化的道路。 另外：用药程序上，一般都少了