《改后郑积华实用癌杂志意见反馈.docVIP

修改意见： 标有“？”号的请认真核对修改。 编辑修改的请核对无误后点击批注框中的“接受修订”。 中英文摘要及文献认真复核，全文前后必须保持一致。 中英文摘要必须一致，补充英文作者名及单位。 5.全文数据请作者认真复核无误，如有疑问请电询0791若修回不合格，编辑不再复审。　　　　　　　　 TS和DPD mRNA对替吉奥治疗晚期胃癌的疗效预测 郑积华 （广州军区广州总医院肿瘤科 广东广州 510010） 作者简介:郑积华(1974一)，男，浙江江山人，硕士，主治医师，主要从事肿瘤内科临床工作。联系地址：广州军区广州总医院肿瘤科　邮编510010 电 [摘要] 目的：评价晚期胃癌患者外周血中的TS (胸腺合成酶)以及DPD (二氢嘧啶脱氢酶) mRNA的表达对替吉奥化疗疗效的预测作用。方法： 应用替吉奥治疗晚期胃癌患者34例，对患者外周血中的TS mRNA以及DPD mRNA的表达情况进行检测，并与化疗效果之间的关系进行评价。结果：替吉奥治疗有效患者的TS mRNA值为（1.57±0.31），无效患者的TS mRNA值为（2.83±0.43），差异有统计学意义（P＜0.05）；替吉奥治疗有效患者的DPD mRNA值为（1.15±0.37），无效患者的DPD mRNA值为（0.98±0.22），差异无统计学意义（P﹥0.05）。结论：外周血中TS mRNA低表达的患者对口服替吉奥化疗的敏感性高，疗效较好，但口服替吉奥化疗的疗效与外周血中DPD mRNA的表达情况无显著相关。 [关键词] 晚期胃癌；替吉奥；二氢嘧啶脱氢酶；胸腺合成酶； The forecast evaluation about curative effect of TS and DPD mRNA on oteracil treating patients with advanced gastric cancer Oncology department of Guangzhou general hospital in guangzhou military region GuangZhou in GuangDong province 510010 About The Author: Zheng Jihua(1974一), male, from Jiangshan in ZheJiang province amd a postgraduate, is the attending doctor. He mainly works on tumor clinical department of Internal Medicine. Address: oncology department of Guangzhou general hospital in guangzhou military region Postal Code: 510010 Telephone number: [Abstract] objective: to forecast clinical value of oteracil on forecasting TS mRNA and DPD mRNA in peripheral blood of patients with advanced gastric cancer. Method: choose 34 cases with advanced gastric cancer who were accepted by our hospital during July,2011 and July, 2013 and were treated with oteracil as the research subjectS. Then to test expression of TS mRNA and DPD mRNA in patients with peripheral blood and to evaluate the relationship with effectiveness of the chemotherapy. Result: after oteracils treating, the value of TS mRNA from patients with effective effect is （1.57±0.31）, the value of TS mRNA from patients with invalid effect is （2.83±0.43）. The difference has a statistical signif