过敏原检测方法分析.ppt

皮肤实验结果解释 如果病史提示敏感性 还有皮肤实验结果阳性 然后与抗原相关的可能性极强 如果病史不提示敏感性 皮肤实验结果阳性 在高强度的自然暴露中观察患者 病史提示敏感性 皮肤实验结果阴性 1 回顾患者用药情况，抗组胺、抑郁药 2回顾其他引起假阴性实验原因如： 劣质的实验材料和技术不恰当 3在高强度自然暴露中观察患者 4 进行激发试验（很少做） 帕特深 变态反应性疾病 人民卫生出版社 2004 Diagnosis and Identification of Causative Allergens Confirmation of allergy and identification of causative allergens are crucial to correctly manage allergic diseases Precise diagnosis allows the implementation of therapies oriented to the etiologic factors of allergic diseases, such as environmental measures and immunotherapy WAO White Book on Allergy2011-2012: Executive Summary Diagnosis begins with a detailed medical history and physical examination. The identification of a temporal association between symptoms and allergen exposure constitutes the basis for further testing Clinical suspicion is confirmed by means of investigation of IgE antibodies in vivo (skin tests) or in vitro. Skin tests should include relevant llergens and the use of standardized allergen extracts. In vitro testing is especially useful when skin test results do not correlate with the history or cannot be performed. In vitro tests can be applied to “probability of disease” prediction in food allergy. There is a need for increased accessibility to allergy diagnosis and therapies and improved diagnostic methodologies that can substitute in vivo provocation tests for drug and food allergy. The use of unproven tests increases the unnecessary costs of allergy diagnosis. 使用未经证实的测试增加了不必要成本过敏原的诊断 全定量检测特异性IgE——ImmunoCAP L. Soderstrom, G. Lilja, M. P. Borres, and C. Nilsson。Allergy 2011;