【2017年整理】假阿洪病一例.docx.docxVIP

网址： HYPERLINK 第 PAGE 1 页，共 NUMPAGES 1 页 钙泊三醇外用治疗可减少银屑病皮损中ICAM-3阳性浸润细胞的表达 钙泊三醇外用治疗可减少银屑病皮损中ICAM-3阳性浸润细胞的表达 中华皮肤科杂志 1998年第6期第31卷 论著 作者：蔡绥勍　郑敏　孙国均 单位：310009 杭州，浙江医科大学附属第二医院皮肤科 关键词：银屑病；钙泊三醇；胞间粘附分子 【摘要】　目的　了解钙泊三醇局部外用治疗对银屑病皮损中细胞间粘附分子3 (ICAM-3) 表达的影响。方法　采用ABC免疫组化法对20例银屑病患者皮损与非皮损部位以及皮损部位治疗前后的ICAM-3、Ki-67和其它免疫分子的表达进行了研究。结果　银屑病皮损部位ICAM-3阳性浸润细胞的表达均明显高于非皮损部位及正常对照组(P均＜ 0.01)，而且ICAM-3的表达和皮损部位Ki-67、CD3等免疫分子的表达呈正相关。经钙泊三醇外用治疗6周后，皮损部位ICAM-3、Ki-67和CD3的表达均明显减少(P均＜ 0.01)。结论　外用钙泊三醇治疗银屑病的机制除了有抗角朊细胞增殖的作用外，对可能参与银屑病发病机制的ICAM-3阳性浸润细胞也有作用。 Topical Treatment of Calcipotriol Decreases Expression of ICAM-3 Positive Infiltrating Leukocytes in Psoriatic SkinCai Suiqing, Zheng Min, Sun Guojun. Department of Dermatology, the Second Affiliated Hospital of Zhejiang Medical University, Hangzhou 310009 【Abstract】　Objective　To study the effect of topical calcipotriol treatment on the expression of ICAM-3 molecule in infiltrating leukocytes of skin lesions of patients with psoriasis before and after treatment.Methods　Expression of ICAM-3,Ki-67 and CD3 was studied in the skin biopsies from 20 patients with chronic plaque type psoriasis before and after topical calcipotriol treatment by using an immunohistochemical technique?Avidin Biotin Complex (ABC) System.Results　ICAM-3, Ki-67 and CD3 positive staining cells in the skin lesions were significantly higher than those in uninvolved skin as well as those of normal controls, and there was a positive correlation between the lesional expression of ICAM-3 and Ki-67 molecules, as well as between lesional expression of ICAM-3 and CD3 molecules. After six weeks of topical application with cacipotriol, the expression of ICAM-3, Ki-67 and CD3 in involved skin were significant decreased (P＜ 0.01).Conclusion　It is indicated that the ,mechanism of topical treatment with calcipotriol in psoriasis involves not only inhibiting keratinocyte proliferation, but also effecting ICAM-3 positive infiltrating leuk