还元注射液对急性脑出血患者血浆内皮素与降钙基因相关肽的影响.docVIP

还元注射液对急性脑出血患者血浆内皮素与降钙基因相关肽的影响 　　内容提要　目的：阐明还元注射液治疗急性脑出血的作用机理。方法：将45例急性脑出血患者随机分为还元组和甘露醇组，分别给予还元注射液和20%甘露醇治疗，并辅以维生素C、10% KCl等静脉滴注，共治疗2周。于治疗前、后分别测定血浆内皮素(ET)、降钙基因相关肽(CGRP)。结果：治疗2周后，还元组较治疗前血浆ET水平明显降低，CGRP含量明显增高(P＜0.01)；甘露醇组治疗前后无统计学差异(P＞0.05)；两组治疗后比较，血浆ET与CGRP均有显著性差异(P＜0.05)。结论：还元注射液治疗急性脑出血的作用机理与降低患者血浆ET水平，提高CGRP含量有关。 Effect of Huanyuan Injection on Plasma Endothelin and Plasma Calcitonin Gene-Related Peptide in Acute Intracerebral Hemorrhage 　　Objective: To study the mechanism of Huanyuan injection in treating acute intracerebral hemorrhage.Methods: Forty-five patients were divided into Huanyuan group and mannitol group who were treated with Huanyuan injection and mannitol intravenously for two weeks respectively. Meanwhile, the two groups were also treated with vitamin C, potassium chloride, etc, intravenously. Plasma endothelin (ET) and calcitonin gene-related peptide (CGRP) levels were determined before and after treatment.Results: After treatment for two weeks, changes of plasma ET and CGRP in mannitol group was insignificant (P＞0.05). Compared with the two treated group, There was obvious significance in plasma ET levels and CGRP content (P＜0.05).Conclusion: Therapeutic mechanism of Huanyuan injectionamp;nbs p;in treating acute intracerebral hemorrhag were correlated to reduce plasma ET and raise the CGRP levels. 　　Key words　Huanyuan injection, acute intracerebral hemorrhage, plasma endothelin, plasma calcitonin gene-related peptide 　　还元注射液由黄芪、生地等中药配伍组成，具有益气养阴，扶正还元，引血下行之功效，治疗急性脑出血疗效显著。为探讨其作用机理，我们观察了治疗前后血浆内皮素(ET)、降钙基因相关肽(CGRP)含量的变化。 　　资料与方法 　　1　临床资料　病例选择发病48h内，就诊于上海中医药大学附属曙光医院急诊科、并留观治疗的脑出血患者45例，全部患者均经头颅CT证实，出血量＜40cm3。所有病例符合1995年中华医学会第4次全国脑血管病学术会议制定的诊断标准(1)。脑干出血、单纯蛛网膜下腔出血、脑外伤引起的出血，合并严重肺部感染，心、肝、肾功能衰竭，严重糖尿病者排外。将45例患者用信封法随机分为还元组和甘露醇组。还元组22例，男性17例，女性5例；年龄53～85岁，平均(72.82±7.63)岁；意识障碍者14例，神经功能缺损积分(2)为(28.59±11.43)分；出血部位：基底节区15例，脑叶5例，小脑2例。甘露醇组23例，男性15例，女性8例；年龄54～84岁，平均(73.04±6.72)岁；意识障碍者15例，神经功能缺损积分为(29.96±10.63)分