出凝血功能的常用检测方法__培训课件.pptVIP

* Factor Xa, Factor Va, calcium ions, and phospholipid membrane combine to form the prothrombinase complex. A single prothrombinase complex converts many molecules of prothrombin (Factor II) to thrombin (Factor IIa). * Conversion of fibrinogen to fibrin involves the cleavage by thrombin of peptide bonds, causing the release of fibrinopeptides A and B. * Platelets adhere to areas of denuded endothelium, forming a monolayer. The platelet GP Ia/IIa receptor binds subendothelial collagen whereas the GP Ib/IX receptor binds von Willebrand factor. * Platelets “filling” the defect caused by endot