2014年度国家科技奖推荐项目简介-湖北省科技厅.doc

2014年度国家科技奖推荐项目简介 拟推荐奖种： 自然科学奖 项目名称： 中国蝎及其毒素遗传资源研究 主要完成人：李文鑫、吴英亮、曹志贱、邸智勇、韩松 项目简介、立项背景： 1995年沿着“蝎物种资源、毒素遗传资源和毒素功能及机制”总体思路，一直进行系统深入研究。主要原创性成果为： 1、系统调查、分类鉴定蝎物种资源并整理编目了“中国蝎物种名录和检索表”，获得我国蝎目物种的种群分布特征和资源现状，填补我国该领域空白。 2、创建了高质量蝎毒素基因库的新方法，首次实现了蝎毒素遗传资源永久保存和利用，开拓了蝎毒素研究、应用新领域，引领蝎毒素学乃至动物毒素学研究。发现了21个毒素类型727个新毒素分子发现了抗病毒抗肿瘤、抗类风湿关节炎等一大批具有重要生物学功能的蝎毒素 8篇代表性论文专著名称及作者 1. Zhu SY, Li WX, Zeng X, Jiang DH, Mao X, Liu H. Molecular cloning and sequencing of two short chain and two long chain K+ channel-blocking peptides from the Chinese scorpion Buthus martensii Karsch. FEBS Letters, 1999, 457: 509-514 2. Luo F, Zeng XC, Hahin R, Cao ZJ, Liu H, Li WX. Genomic organization of four novel nondisulfide-bridged peptides from scorpion Mesobuthus martensii Karsch: gaining insight into evolutionary mechanism. Peptides, 2005, 26: 2427-2433 3. Yi H, Cao ZJ, Yin SJ, Dai C, Wu YL, Li WX. Interaction simulation of hERG K+ channel with its specific BeKm-1 peptide: insights into the selectivity of molecular recognition. J Proteome Res, 2007, 6: 611-620 4. Han S, Yi H, Yin SJ, Chen ZY, Liu H, Cao ZJ, Wu YL, Li WX. Structural Basis of a Potent Peptide Inhibitor Designed for Kv1.3 Channel, a Therapeutic Target of Autoimmune Disease. J Biol Chem, 2008, 283: 19058-19065 5. Ma YB, Zhao RM, He YW, Li SL, Liu J, Wu YL, Cao ZJ, Li WX. Transcriptome analysis of the venom gland of the scorpion Scorpiops jendeki: implication for the evolution of the scorpion venom arsenal. BMC Genomics, 2009, 10: 290 6. Ma YB, Zhao Y, Zhao RM, Zhang WP, He YW, Wu YL, Cao ZJ, Guo L, Li WX. Molecular diversity of toxic components from Asian forest scorpion (Heterometrus petersii) venom revealed by proteomic and transcriptome analysis. Proteomics, 2010, 10: 2471-2485 7. Di ZY, Wu YL, Cao ZJ, Xiao H, Li WX. A catalogue of the Genus Euscorpiops Vachon, 1980 (Scorpiones: Euscorpiidae, Scorpiopinae) from China, with description of a new species. Zootaxa, 2010, 2477: 49-61 8. Yu XF, Sun Z, Li M, Xiang Y, Wang QQ, Tang F, Wu YL, Cao ZJ, Li