ANCA相关小血管炎的诊治策略和研究进展2015.ppt

426 patients,：Wegener’s granulomatosis，87 (20.4%) Microscopic polyangiitis，337 (79.1%) Churg-Strauss syndrome，2 (0.5%) All patients had multisystem involvement. kidney involvement，371 (87.1%) lung involvement，260 (61.0%) Renal involvement ： MPO-p-ANCAPR3-c-ANCA The one（ 13.1% ）and five year （22.4%）death rates The end stage renal disease at one（15.9%）and five years（27.1%） Conclusions: AAV is not a rare autoimmune disease in Chinese people. Kidney and lung were the most vulnerable organs. M Chen Postgraduate Medical Journal 2005;81:723-727 Renal Division and Institute of Nephrology, Peking University First Hospital, Beijing， Characteristics of Chinese patients with ANCA-associated systemic vasculitides 234 patients ：99（≥ 65 years),135 younger patients The older patients ：MPO-p-ANCA，94.9% The younger patients：MPO-p-ANCA，80.0% The older patients：MPA ,79.8% ；WG,18.2% ； RLA,0% The younger patients: MPA,50.4%；WG,37.8%；RLA, 11.1% Pulmonary involvement： The older The younger Conclusion：compared with younger patients, older patients with AAV had more severe and more prevalent pulmonary lesions, which might contribute to subsequent pulmonary infections after the initiation of immunosuppressive therapy. Age and pulmonary infection were independent predictors of death. ANCA-associated vasculitis in older patients M Chen；Department of Medicine, Peking University First Hospital, Beijing, China. 500 Chinese patients with AAV. 89 WG: MPO-ANCA positive（60.7%) PR3-ANCA positive (38.2%) . Patients with MPO-ANCA had multisystem involvement. The prevalences of arthagia, skin rash, ophthalmic and ear involvement： patients with MPO-ANCA (20.4~46.3% ） patients with PR3-ANCA （27.8~70.6%） CONCLUSION: Patients with MPO-ANCA positive WG were not rare in Chinese. M Chen； Renal D