芪灵肺宝丸联合化疗治疗中晚期非小细胞肺癌的疗效观察.doc

芪灵肺宝丸联合化疗治疗中晚期非小细胞肺癌的疗效观察 伍明辉　(浏阳市中医院,浏阳410300) [摘要] 　目的:探讨芪灵肺宝丸联合化疗治疗中晚期非小细胞肺癌的临床疗效。方法:将66例中晚期肺癌患者随机分为治疗组33 例和对照组33 例，对照组第1 d、第8 d给予吉西他滨1250g／m2，第1～3 d给予顺铂30mg／m2;治疗组化疗方案同对照组,化疗前5天开始给予芪灵肺宝丸口服，连用14 d 为一周期,每间隔21 d重复治疗,共3个周期。结果:治疗组近期有效率为66. 66% ,对照组近期有效率为42.42 %( P 0. 05) ;生活质量改善率治疗组为78. 78% ,对照组为51.51 %( P 0. 05) ;治疗组不良反应发生率分别为白细胞39.39 % ,血小板48. 48 % ,恶心、呕吐33.33%;对照组不良反应发生率分别为白细胞57.57 % ,血小板69. 69 % ,恶心、呕吐45.45 %。结论: 芪灵肺宝丸联合化疗治疗中晚期非小细胞肺癌能够提高临床疗效，减轻化疗药物的毒副反应，改善患者的生活质量。 [关键词] 　 芪灵肺宝丸;化疗;中晚期非小细胞肺癌;疗效观察 Qi-ning-fei-bao wan Combined with Chemotherapy in Treatment of non-small cell lung cancer WU Minghui( Liuyang Hospital of Chinese Medicine ,Liuyang 410300 ,China) Abstract:Objective To observe efficacy on Qi-ning-fei-bao wan combined with chemotherapy in treatment of non-small cell lung cancer .Methods Sixty-six patients with more advanced or advanced NSCLC were randomly assigned to two groups.The treatment group 33cases ,and the control group 33 cases. Control group :Gemcitabine Hydrochlride for injection :1250mg·m2 ,d1 ,d8 ;Cisplatin for injec- tion :30 mg·m- 2 ,d1-3 ;treatment group : Qi-ning-fei-bao wan 9g ,po ,tid,five days before chemother- apy;14days as a period ,the intervat was 21 days ,total 3 periods. Results The shortterm effect rate of treatment group was 66. 66 % and the conrol group was 42. 42 % , P 0. 05 ;quality of life improve- ment rate : treatment group was 78. 78 % ,control group was 51.51 % , P 0. 05 ;ADR of treatment group : WBC39. 39 % ,PLT 48. 48 % , nausea 、vomit 33. 33 %;ADR of control group :WBC% , PL T 69. 69 % , nausea ,vomit 45. 45 %. Conclusion Qi-ning-fei-bao wan combined with chemo- motherapy in treatment of non-small cell lung cancer could improve the clinical efficacy，reduce toxicity of chemotherapy drugs and improve the patient’s quality of life． Key Words : Qiing-fei-bao wan;chemotherapy ; non-small cell lung cancer (NSCLC);efficacy 多数非小细胞肺癌确诊已为中晚期, 临床发现约2/3的病例失去了手术的机会［1］，所以综合治疗是中晚期非小细胞肺癌的最佳治疗手段。中西医结合综合治疗中晚期非小细胞肺癌是我国的特色,它融