血清肿瘤相关物质(TAM)检测在肿瘤诊断中的应用价值.docVIP

血清肿瘤相关物质（TAM）检测在肿瘤诊断中的应用价值 王君哲?牟君成?范慧?程联 ???????????????????????????（重庆万州???重庆三峡中心医院?404000） 摘要 ??目的： 探讨肿瘤相关物质检测TAM（BXTM）在肿瘤诊断中的应用价值。 方法 采用生化法对155例恶性肿瘤患者(A 组)，103 例非肿瘤患者(B 组)和1000例健康体检人员(C 组)的血清肿瘤相关物质浓度进行检测，用统计学方法统计分析观察各组中血清肿瘤相关物质含量的关系。 结果：? 血清中肿瘤相关物质 含量：A 组（100.84 ±13.08 U/ ml）明显高于B 组（86.67 ±10.33U/ ml）和C 组（81.45±9.69 U/ ml ）( P 0. 01)。B 组中自身免疫系统疾病阳性率为31.25%，血清肿瘤相关物质测定恶性肿瘤的敏感性为73.55% ，良性肿瘤特异性为82.85%，健康体查特异性高达98.4%。结论：? 血清肿瘤相关物质检测对恶性肿瘤的早期辅助诊断，良、恶性肿瘤的鉴别诊断以及人群普查有较为重要的价值，具有很高的敏感性、特异性和广谱性。自身免疫系统疾病对血清肿瘤相关物质有较强的干扰性，使用时应注意鉴别。 【关键词】? 肿瘤相关物质; ??肿瘤; ??诊断 Value of serum tumor associated material( BXTM) detect in diagnosing malignant tumor WANG Jun-zhe, MU Jun cheng, FAN Hui ,CHENG Lian The Central Hospital of Chongqing Sanxia ,Chongqing 404000 ,China 【Abstract】Objective To investigate the role of serum Tumor associated Material TAM(BXTM) in early diagnosing malignant tumor? Methods The level of TAM(BXTM) in serumwas measured in 155 cases of malignant tumor(Agroups),103 cases of non - malignant tumor(B groups) and 1000 cases normal people(C groups). ?Results The level of TAM(BXTM) in serum of A groups（100.84 ±13.08 U/ ml）was significantly higher than that of B groups（86.67 ±10.33U/ ml） and C groups（81.45±9.69 U/ ml ）and controls（p0.01）. The sensibility of serum tumor-associated malignant tumors was 73.55%, and the specificity of benign tumors was 82.85%, the specificity of Health-check was up to 98.4%. Conclusion ??It has been testified that the measurement on the content of TAM(BXTM) can give effective reference for? early detection of tumor, differentiation between carcinoid and malignancy,And it has the characteristics of highly sensitive ,specific and broad - spectrum. Autoimmune disease should be considered in diagnosing the malignant tumor by TAM(BXTM) 【Key words】? tumor associated material TAM(BXTM); tumor; diagnosing ? 恶性肿瘤是威胁人类健康和生命的主要疾病之一。据统计，中国每年死于肿瘤的人近百万，已经成为仅次于心脑血管疾病死亡的病因。肿瘤相关物质是指恶性肿瘤细胞异常产生和人体正常细胞对肿瘤反应所产生的物质，主要为糖蛋白、脂蛋白、羟脯氨酸等。临床研究表明：肿瘤发生时，血液中肿瘤相关物质含量升高[1]，是早期发现肿