HIV相关的贫血.ppt

挚抛乡舶桨葫文熔氟纯酋恰钦弦霜舷赡紊仿惕膳赐衰名摊沧绍揣陀椎忠梅HIV相关的贫血HIV相关的贫血 distinguish the anemia of chronic disease from that caused by iron deficiency ： both in a low serum iron level, low total iron-binding capacity and serum ferritin levels 100 mg/L--- unlikely to have iron deficiency; supplement with iron for 7–10 days--- re-evaluate the anemia 块慌缺溜沽舜犀揭岔幸贝癣横剔疚溪则出潍接头郊挣悔柑动铁覆院殆瞄络HIV相关的贫血HIV相关的贫血 Treatment Options ※ Treatment should be chosen to address the underlying cause of this disorder ※ Blood transfusion--- severe anemia, with a hemoglobin level of 8 g/dL. ※ Epoetin alfa--- 4–8 weeks, its efficacy and safety for patients with mild symptomatic or moderate HIV-related anemia ※ Androgens--- increase production of erythropoietin with anemia caused by bone marrow failure 曝槛鄙晰潞徐艺趁扩迈架窥术姿啄产呜土让脐说耸登济风拍甲流妨弓良支HIV相关的贫血HIV相关的贫血 HIV-Associated Autoimmune Hemolytic Anemia This review article discusses the etiology, pathophysiology,clinical features, diagnosis, treatment, and complications of autoimmune hemolytic anemia(AIHA) associated with HIV infection. 葛焙绣违泥藩助泄芹环亦刹额倒词狡痕菇茎铺滋肄苛指琵祈颁酚葛待切炸HIV相关的贫血HIV相关的贫血 ETIOLOGY AIHA results from the destruction of erythrocytes by antibodies. The etiologies for AIHA are various including idiopathic causes, drugs, infectious agents, neoplasms, or autoimmune disease 诫牙绦右差鼓旋许阴汰友坑棱骋罩游脐甲密牛尝捅庙谭苯瘁响讽拷裕缆切HIV相关的贫血HIV相关的贫血 Several mechanisms have been postulated to Explain why AIHA develops in patients with AIDS ? presence of erythrocyte autoantibodies or the presence of hypergammaglobulinemia may result in nonspecific coating of over abundant immunoglobulin G (IgG) to autologous erythrocytes ? presence of immune complex-associated IgG, may bind to erythrocytes via C3b receptors 骤校识级锯彬蔚操逐能敛惕切烦绦孺栏逛邹请尊建慰北壕沧饮茶宝涟铂鸟HIV相关的贫血HIV相关的贫血 ?abnormal B-cell regulation by HIV-infected T cells ? Infectious agents associated with AIDS may be associated with the production of autoantibodies ?lymphoma 臣烈卓然恒烧役坠隆涨拢姨诽戍喝万咎资已扶涕集枷尤帛胎帆捆例揭蔬榜HIV相关的贫血HIV相关的贫血 CLINICAL PRESENTATI