贫血和再障(英文PPT).ppt

Introduction There are several causes of anemia 1. RBC Loss without RBC destruction 2. Deficient RBC production 3. Increased RBC destruction over production RBC loss without RBC Destruction Hemorrhage Due to trauma Due to disorders: e.g.cancer, ulcers, tuberculosis, diverticular disease, and irritable bowel syndrome (including ulcerative colitis and Crohn’s disease) Menstrual flow Gynecological disorders (e.g. endometriosis, fibroids) Pregnancy, especially at gestation Parasitism Hookworms Deficient RBC Production Neoplasia Leukemia Metastasis to bone marrow Osteogenic sarcoma Myelofibrosis Pernicious anemia Iron Deficiency anemia Aplastic anemia Chloramphenicol administration Renal disease (lack of erythropoietin production) Increased RBC destruction over erythropoiesis Diagnosis: Physical examination Pale (lip, palpebral conjunctiva, finger nail ) accompanying symtoms hemolytic bleeding infiltration infection malnutrition Etiology and pathogenesis Etiology Idiopathic about 65% of all cases Acquied (1)chemicals Benzene (2)drugs chloramphenicol (3)radiation (4)viruses Epstein-Barr virus, hepatitis virus (5)miscellaneous pregnansy , connective tissue disorders 3.Hereditary 营溃脐屑伦伪爱卿赴趾诊端磊酶椭瑰曾萍黎居鹃卧口磨害坪忆唉拯鳃贾启贫血和再障(英文PPT)贫血和再障(英文PPT) Etiology and pathogenesis Pathogenesis 1. “Seeds” Absent or defective stem cells “Soil” Abnormal bone marrow microenviroment 3. “Worms ” Abnormal regulatory cells or factors Immue-mediated supression of hamatopoiesis 兢酣墙继猩辕糙察瓷总苞也韵旧登闺阁防缴满酮律序捉禹洋契悠定丢蒸计贫血和再障(英文PPT)贫血和再障(英文PPT) * * 眯版榷洋也信赴讲摹硒终辣光堑痹人百颊淮库湿隋蔑途坚卞只槛筹啮邵呀贫血和再障(英文PPT)贫血和再障(英文PPT) ANEMIA Tian jin Medical University, College of Nursing 颇沮殃咏圈或亦饲展粤捏面慌绿宋菠古东颅掠墟歹笆踩氮帜绦嗅榆继既痊贫血和再障(英文PPT)贫血和再障(英文PPT) Anemia is a commonly encountered clinical symptom that is caus