骨科植入物局部生命化课稿.ppt

Microstructure of Ti6Al4V/silk fibroin composite scaffold 体外细胞培养实验 Pure Ti Ti + Chs Ti + Chs + HA Pure Ti Ti + Chs Ti + Chs + HA Cell morphology on scaffolds for 7 and 14 days 动物实验 羊髂骨缺损 12 周取样 动物实验 动物实验 小结 金属3D打印技术能够实现骨科植入物复杂外形和内部孔隙结构的可控性制造； 通过优化杆件尺寸等参数，可以精确调控植入物孔隙结构特征及力学性能，实现植入物与宿主骨的力学适配； 多孔钛与聚合物海绵形成的复合结构，实现了多孔钛力学性能与天然聚合物海绵物理化学及生物学性能的完美融合，细胞接种率获得大幅提升，促进了新骨的形成与长入。 期盼 Adler Ortho FDA, CE 认证 谢谢！ * A great number of osteoblasts attached to the (A–B) pure porous titanium scaffolds and (C–D) porous titanium scaffolds with biomimetic coating, and presented an elongated morphology with cytoplasmic extensions on scaffolds. There were no obvious differences in cell adhesion and morphology between the uncoated and coated samples. The cells on the porous titanium exerted a high and sustained proliferation rate within 14 days, and no significant difference was observed between the uncoated and coated samples at each timepoint. * The images showed that the rapid increase of bone ingrowth into the pores of titanium throughout the experiment and close contact between bone tissue and EBM implants at 12 weeks post-surgery, while there were no obvious differences between the uncoated and coated samples at each timepoint. * The data showed a high percentage of newly formed bone in the defect region in both coated and uncoated implants during the whole experiment (P.0.05). * After 1, 4, and 7 days of culture, more cells were present on Ta-coated scaffolds suggesting higher proliferation when compared with Ti6Al4V scaffolds (p b 0.05). * * It is reported that the pore size of polymer sponges can be easily controlled by selecting the solution concentration and the freezing temperature. 骨科植入物局部生命化 上海交通大学机械与动力工程学院 生物医学制造与生命质量工程研究所 骨科植入物的类型 脊柱类 关节类 创伤类 Combustor Liner Robot Arm Acetabular Cup Blast Resistant Panel 金属3D打印技术 标准系列产品 多孔钛合金个体化植入物 个体化植入物 金属3D打印技术开辟了骨科植入技术的新纪元 以激光为能量源 以电子束为能量源 金属3D打印技术 金属3D打印技术 德国 Concept Laser M2 激光熔融成型技术（Selective Laser Melting, SLM） 瑞典 Arcam A1 电子束熔化成型技术（E