-斑蝥酸钠维生素b注射液联合同步放化疗治疗中晚期宫颈癌的临床观察.docVIP

斑蝥酸钠维生素Ｂ6注射液联合同步放化疗治疗中晚期宫颈癌的临床观察 黄辉1刘美莲1白雪1何卓凯1李思维1蔡锐1赵博1张荣君1陈秋秋1柳正春1蒋宏玲2 （1.桂林医学院附属医院放疗科，广西桂林541001；2. 桂林医学院附属医院康复科） 摘要：目的 观察斑蝥酸钠维生素Ｂ6注射液联合同步放化疗治疗中晚期宫颈癌患者的疗效及不良反应。方法 将84例中晚期宫颈癌患者随机分为A、B 两组，两组均采用同步放化疗且放化疗方式相同，A组43例，在同步放化疗基础上加用斑蝥酸钠维生素Ｂ6注射液0.5mg，1日1次，至放疗结束；B组41例，采用同步放化疗，不使用斑蝥酸钠维生素Ｂ6注射液。结果 A组完全缓解（CR）率为69.77%，B组完全缓解（CR）率为43.90%，差异有统计学意义(P0.05)；A组生活质量Karnofsky评分高于B组，差异有显著性(P0.05)；A组血液不良反应、胃肠道反应明显低于B组，差异均有显著性(P0.05)。结论 斑蝥酸钠维生素Ｂ6注射液联合同步放化疗治疗中晚期宫颈癌，能提高肿瘤完全缓解（CR）率，改善患者的生活质量，降低放化疗对患者的不良反应。 关键词：宫颈癌；同步放化疗；斑蝥酸钠维生素Ｂ6注射液；生活质量；不良反应 Clinical Observation on Sodium Santharidinate and Vitamin B6 Injection Combined with Concurrent Radiochemotherapy for Advanced Cervical Cancer Huang Hui，Liu Meilian，Bai Xue，He Zhuokai，Li Siwei，Cai Rui，Zhao Bo，Zhang Rongjun，Chen Qiuqiu，Liu Zhenchun，Jiang Hongling. Department of Radiation Oncology，Affiliated Hospital，GuiLin Medical College，Guilin 541001，China. ABSTRACT OBJECTIVE: To evaluate the efficacy and adverse reactions of Sodium Santharidinate and Vitamin B6 injection combined with concurrent radiochemotherapy for advanced cervical cancer. METHODS: A total of 84 patients with cervical cancer were randomly assigned to receive either radiochemotherapy plus Sodium Santharidinate and Vitamin B6 injection at a dose of 0.5 mg qd (Group A,43 patients) or radiochemotherapy alone( Group B, 41 patients).RESUITS: There were significant differences in the complete remission(CR) rate between Group A and Group B(69.77% vs. 43.90%，P0.05).The Karnofsky score of life quality was significantly higher in Group A than in Group B，showing significant differences between the ___________________________________ 基金项目: 广西卫生厅科研课题项目资助（Z2011185）。 黄辉：男，湖南安化人，放射医学硕士研究生，副主任医师，研究方向为肿瘤放射治疗和综合治疗，Tel：（0773）2882906；Email：huanghui25002@163.com。 通信作者: 蒋宏玲Tel：（0773）2882906；Email：594664207@。 two groups(P0.05).The haematologic toxicities and gastrointestinal reactions were significantly milder in Group A than in Group B,all showing significant differences(P0.05). CONCLUSION: Sodium Santhar