围手术期质子泵抑制剂预防应激性溃疡合理性评价与分析.PDFVIP

92 中国药事 2017 年 1 月 第 31 卷 第 1 期 ·合理用药 · 围手术期质子泵抑制剂预防应激性溃疡合理性评 价与分析 * 曾秀琴，杜柏荣，谢希晖，李媛媛，刘静 （酒泉市人民医院， 酒泉 735000） 摘要 目的： 调查酒泉市人民医院外科围手术期使用质子泵抑制剂 (PPIs) 预防应激性溃疡 (SU) 的情况， 促进合理用药。方法：随机抽查酒泉市人民医院 2015 年 6-12 月外科手术出院病历 700 份，对围手术期 使用 PPIs 预防 SU 的患者进行合理性评价与分析。结果：使用 PPIs 预防 SU 的 339 例患者中，26.25% 有 预防用药指征。有预防用药指征的患者中，用药品种以奥美拉唑为主，占 69.66%；给药途径及用法用量 合理率分别为 30.34%、75.96%；给药时机及用药疗程合理率分别为 51.69%、39.33%。结论：酒泉市人民 医院对质子泵抑制剂 (PPIs) 预防围手术期患者应激性溃疡 (SU) 存在一些误区，需要加强管理，防止其过 度使用。 关键词： 围手术期；应激性溃疡；质子泵抑制剂；合理用药；预防用药；过度使用 中图分类号：R969.3 文献标识码：A 文章编号： 1002-7777(2017)01-0092-04 doi:10.16153/j.1002-7777.2017.01.018 Evaluation and Analysis on the Rationality of Proton Pump Inhibitors Use for Prevention of Stress Ulcer in the Perioperative Period * Zeng Xiuqin, Du Bairong, Xie Xihui, Li Yuanyuan, Liu Jing (Jiuquan People’s Hospital, Jiuquan 735000, China) Abstract Objective: To investigate the situation of proton pump inhibitors use for prevention of stress ulcer in perioperative patients, so as to enhance the level of rational drug use. Methods: The data of 700 surgical patients discharged from our hospital from June 2015 to December 2015 were randomly collected for statistical analysis regarding the rationality of proton pump inhibitors use for stress ulcer prevention in perioperative patients. Results: Of the total 339 cases with PPIs use, only 26.25% were with indications for stress ulcer, among which 69.66% of the PPIs used were omeprazole; the rationality rate of the administration and dosage was 30.34% and 75.96% respectively; 51.69% of the surgical patients used PPIs at the right time, and 39.33% were with the right course of treatment. Conclusion: The application of PPIs for stress ulcer prevention in perioperative patients in our hospital is far from perfection; and g