microRNA-506在不同肿瘤中作用的研究进展.PDFVIP

120 中国肿瘤临床2016年第43卷第3期 ChinJClinOncol2016.Vol.43.No.3 国家基金研究进展综述 · · microRNA-506在不同肿瘤中作用的研究进展* 张靖宜 孙燕 摘要 microRNA-506是存在于X染色体上的一种microRNA，通过对靶基因的转录后调控影响细胞增殖、凋亡、衰老、细胞周期、 细胞分化、上皮-间质转化、血管生成、侵袭和转移等多种生命过程。目前发现，microRNA-506在多种肿瘤的发生发展过程中发 挥重要的作用，细胞学和动物实验也提示microRNA-506可以抑制一些肿瘤的发生发展，并促进某些化疗药物的疗效。但是，mi? croRNA-506对不同的肿瘤发挥着不同的调节作用。本文对microRNA-506在不同肿瘤中的作用及其作用机制进行总结，旨在为 特定肿瘤的治疗提供新的靶点。 关键词 microRNA-506 肿瘤 抑癌基因 靶向治疗 doi:10.3969/j.issn.1000-8179.2016.03.337 Role of microRNA-506 in different tumors Jingyi ZHANG, Yan SUN Correspondence to: Yan SUN; E-mail: sunyan@ Department of Pathology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin Key Laboratory of Cancer Prevention and Therepy, Tianjin 300060, China This work was supported by the National Natural Science Foundation of China (No. Abstract MicroRNA-506 (miRNA- 506) is located in the X chromosome and influences various processes, such as cell proliferation, apoptosis, senescence, cell cycle, cell differentiation, epithelial- to- mesenchymal transition, angiogenesis, invasion, and metastasis, through post-transcriptional regulation of its targets. Recent studies have shown that miRNA-506 plays an important role in tumorigen- esis and progression of many types of tumors. In vitro and in vivo experiments revealed that miRNA-506 suppresses progression of sev- eral tumors and promotes response of tumor cells to chemotherapy. However, miRNA- 506 plays different roles in different tumors. This review summarizes the functions and mechanisms of miRNA-506 in different tumors to identify a new target for the targeted ther- apy of certain tumors. Keywords: microRNA-506, tumor, tumor suppressor, targeted therapy 微小RNA（microRNAs）是一类短链、非编码RNA miR-510、miR-513和miR-514）的一员，与晚期卵巢 ［4-5］ 分子