《分子 细胞与组织教学课件》细胞团队第20章【课件】.pdfVIP

Function and neural control of muscle cells and gland cells 肌肉和腺细胞的功能及其神经调控 张文慧 生理教研室 Ext: 776446 E-mail: i_zhangwenhui@163.com Learning objectives ? Describe the steps of transmission of excitation at neuromuscular junction ? Describe the process of excitation-contraction coupling in ? Skeletal muscle ? Cardiac muscle ? Smooth muscle ? Understand the excitation-secretion coupling in gland cells ? Define and explain the difference between isometric and isotonic contraction ? Describe the factors that inflence the contractility of skeletal muscle ? Define the channelopathy Contraction of skeletal muscles ? Transmission of excitation at neuromuscular junction ? Excitation-contraction coupling ? Myofilament sliding 肌萎缩性脊髓侧索硬化症（Amyotrophic Lateral Sclerosis ， 简称A ．L ．S ．） The structure of neuromuscular junction ? The neuromuscular junction is made of: ? prejunctional membrane: the axon terminal ? j unction cleft: synaptic cleft ? postjunctional membrane: the motor end plate Steps of neuromuscular transmission (EPP: end plate potential) EPP: a local depolarization (graded potential) MEPP 微终板电位 影响N-M接头处兴奋传递的因素 ? 阻断ACh 受体：箭毒和α银环蛇毒，肌松剂 （驰肌碘） ? 抑制胆碱酯酶活性：有机磷农药，新斯的明 ? 自身免疫性疾病：重症肌无力 （抗体破坏ACh 受体） 肌无力综合征 （抗体破坏N末梢Ca2+通道） ? 接头前膜Ach释放 ↓：肉毒杆菌中毒 Physiological anatomy of striated muscle Excitation-contraction coupling Definition: The sequence of events linking the transmission of an action potential along the sarcolemma to muscle contraction (the sliding of myofilaments). /sites/0072495855/student_view0/chapter10/animation__acti on_potentials_and_muscle_contraction.html 兴奋-收缩耦联 ① 肌膜电兴奋的传导 ② 三联管处的信息传递 2+ ③ 肌浆网（纵管系统）中Ca 的释放