人体生物化学与疾病剖析.ppt

* In contrast, the developing world currently has a relatively young population that is rapidly increasing. The number of elderly people in developing countries will increase more dramatically over the next few decades as the population ages. As a consequence, the number of people with dementia will also rise. Support continued . . . According to Kunst over-expression of normal SOD1 accelerates disease onset and progression However, a decrease or increase in SOD1 activity is not sufficient to cause ALS in mice From PubMed Hypothesis #2 SOD1 may lose its ability to bind zinc (Zn), Copper (Cu), or both This may cause SOD1 to lose its ability to process free radicals From MDA Publications Support from NCBI Zinc and Copper = normal Zinc removed = toxic Zinc and Copper removed = non-toxic Copper removed = not studied yet Zinc that is bound to SOD1 may stabilize the protein From PubMed Support continued . . . Zinc-deficient SOD1 produces more free radicals than it destroys SOD1 mutant can not bind zinc as strongly as normal SOD1 * * * NSE是糖酵解中的关键酶，催化2-磷酸甘油酸裂解生成水及烯醇式丙酮酸。存在于神经组织和神经内分泌系统，当这些部位患癌症时会升高，如小细胞肺癌，神经母细胞瘤等。 * * 脑内ATP丰富时CK活跃，可生成磷酸肌酸而贮存能量，脑内CK为CK-BB（可提问）。 * * * * * * * * * * * Lewy body（1912首次发现） * Artist charts his slide into dementia, Galerie Beckel Odille Boicos, Paris.Six self-portraits by artist William Utermohlen chronicle his experience with Alzheimers disease.Utermohlen was diagnosed at the age of 60.The first in this series (top left) was painted in 1996, just prior to diagnosis. * * 精神分裂症（schizophrenia） 以精神活动互不协调，脱离现实环境为特征，最常见的精神病。 Schizophrenia is a serious mental illness. People who suffer from it are unable to relate their thoughts and feelings to what is happening around them and often withdraw from society * 临床表现： 阳性行为 ——幻觉、错觉和怪异行为 阴性行为 ——社交回避和情绪迟钝等 * * * * 发病机制： 多巴胺功能亢进 遗传因素 * 2014年8月开始的冰桶挑战赛 全称为“ALS冰桶挑战赛”（ALS Ice Bucket Challenge），要求参与者在网络上发布自己被冰水浇遍全身的视频内容，然后该参与者便可以要求其他人来参与这一活动。活动规定，被邀请者要么在24小时内接受挑战，要么就选择为对抗“肌肉萎缩性侧索