DXS6804／DXS9896／GATA144D04基因窿在中国汉族群体中的遗传多态性及其法医学应用.pdfVIP

遗 传HEREDITAS(Beijing)26(5)：603～606，2004 研 究 报 告 ■ DXS68D4／DX 9896／GA 744D04基因座在 ● 中国汉族群体中的遗传多态性及其法医学应用 应斌武，石美森，邓建强，李英碧，吴 谨，颜 静，张 霁，侯一平 (四JII大学华西基础医学与法医学院法医物证教研室，成都610041) 摘 要：为了调查X染色体上DXS6804、DXS9896和GATA144D04等3个STR基因座在中国汉族群体的遗传多态 性及其法医学应用价值，来用PCR和聚丙烯酰胺凝胶电泳对X染色体3个STR基因座进行分型，并检验女性基因 型频率分布是否符合Hardy-Weinberg平衡，计算法医学常用各种概率。DXS6804、DXS9896和GATA144D04的非 父排除率分别为0．5990、0．6220、0．4280，表明3个STR基因座在中国汉族群体均具有遗传多态性，X 检验表明女 性的基因型频率分布符合Hardy-Weinberg平衡。X染色体上的基因座DXS6804、DXS9896和GATA144D04在中 国汉族群体中具有较高的遗传多态性，可应用于法医学检验和群体遗传学分析。 关键词：X染色体；短串联重复序列；遗传多态性；中国汉族 中图分类号：Q987 文献标识码：A 文章编号：0253—9772(2004)05—0603—04 Genetic Polymorphism of 3 STR Loci on Chromosome X and Its Forensic Application in Chinese Population YING Bin-Wu，SHI Mei-Sen，DENG Jian-Qiang，LI Ying-Bi，WU Jin，YAN Jing，ZHANG Ji，HOU Yi-Ping (Institute ofForensicMedicine，Sichuon University，Chengdu 610041，Chino) Abstract：To investigate the genetic polymorphisms of three short tandem repeats loci of chromosome X in Chinese Han population in Chengdu area and its use in forensic science．Three X．chromosome linked short tandom repeat loci were analyzed by PCR followed by polyacrylamide gel eIectrophoresis．Hardy．Weinberg equilibrium was tested and fo． rensic interested value was calculated．The power of exlcution of DXS6804、DXS9896和 GATA 744D04 is 0．5990、 0．6220、0．4280，respectively．The result showed that all the three STR loci were polymorphic among 100 unrelated fe． males and 1 20 unrelated males from Chinese Han population．X tests demonstrated that genotyp