新型口服活性炭球对体内成分的吸附性能研究.pdf

of 5mChineseScienceTechnologyEducationSymposiumPharmaceuticalNov．2006 Enginee—ng 新型口服活性炭球对体内成分的吸附性能研究 陶一丹’’ 顾磊1) 藤娜2’ 高峰’卜 1)华东理工大学药学院；2)华东理工大学化工学院，上海200237 ·男，43岁，博士，副教授，研究方向：生物制药和药物制剂，fgao@ecust．edu．cn 关键词球形活性炭；粉末活性炭；吸附 摘 要 目的：本研究研制沥青基活性炭球，并观察其对内源性物质的吸附性能。方法：将活性炭定量放置千待测溶液 中，恒温震荡3小时后测定上清液浓度，得出吸附率。测定方法包括气相色谱法和紫外分光光度法。结果：球形炭对于 离子性有机小分子化合物的吸附率明显大于粉末炭，活性炭对消化酶的吸附率明显小于粉末炭。结论：球形炭在吸附体 内离子型化合物和消化酶上优于粉末炭。 on ofnoveloral activated Studyadsorptioncapability spherical carbonOn inhuman ingredients TAOYidan 1)，GULei 1)，TENGNa2)，andGAOFeng1)卑 ofChemical 1)CoUegeofPharmacy，and2)College Engineering， EastChina ofScienceand 200237 University Technology；Shanghai words activated activated Key spherical carbon，powdercarbon，absorption AbstractAim：We activated rateofitOilsome developed carbon(PSAC)andadsorption pitch·basedspherical investigated inhuman．Methods：Thecharcoalswere inthesolution。Aftershakeinconstant for3h，the ingredients placed temperature the methodsincluded concentrationswe舱measuredand ratewas supernatant adsorptioncalculated．Detectinggaschromatography andUV．Results：TheresultsshowedthatPSACincreasedthe rateoftheharmfulionic small adsorption organicmolecule，and decreasedthe rateofthe to activatedcarbon．Conclusion：PSAC adsorption digestenzymes，comparingpowder