スライド ek.jp.pptVIP

1日本大学大学院総合科学研究科生命科学、２医学部癌遺伝学分野、３医学部放射線科、４医学部泌尿器科、５医学部薬理学分野、６薬学部臨床薬物動態学ユニット、７日本大学量子科学研究所、８理工学部応用化学 空間干渉Ｘ線源の医療応用：がん治療の革新 A Possible Application of Parametric monochromatic X-ray (PXR) Radiation Induced Photodynamic Therapy ( PDT ) 永瀬浩喜1,2、石橋直也2、3、増子亜矢2，4、五十嵐　潤2、高橋　悟3、高橋元一郎4、石川紘一5 、松本宜明６、阿部克己3 、齋藤勉3 、藤原恭子2 、田中俊成７、早川建７ 、早川 恭史７ 、高橋 由美子７、大月　譲8 、新富孝和１ 、佐藤勇１ 医学研究所　学術フロンティアプロジェクト 「癌感受性遺伝子探索、機能解析、標的評価、新規治療開発、 臨床前試験を一環的に研究する拠点推進プロジェクト」 Ｎ.研究プロジェクト 「ナノ物質を基盤とする光?量子技術の極限追求」医療班 Backgrounds Parametric monochromatic X-ray (PXR), a new class of coherent X-ray, is a tunable single wavelength and single phase X-ray. PXR has been developed by using the electron beam from the 125-MeV linac in Laboratory for Electron Beam Research (LEBRA) of Nippon University. When the PXR are converged, PXR shows a similar characteristic to the Bragg peak of proton beam and heavy ion beam for radiosurgery. Since PXR is a single wavelength and single phase of soft-to-hard X-ray, it minimizes radiation exposure in the surrounding tissues. PXRs have a potential to induce photoexcitation of radiosensitive molecules and establish a new PDT antitumor therapy targeting deep internal tumors and metastatic regions in addition to the direct radiation therapy even. 　 PDT compounds conjugated with Iodine, which may have an absorbance of around 33KeV coherent X-ray and generate a scintillation light of around 420nm for a photosensitivity material. This may activate and generate singlet oxygen in the target disease tissues. 低被爆 放射線　力学療法 深部臓器への治療 Possible Application of X-ray Induced Photodynamic Therapy ( PDT ) がん?腫瘍を 特異的に治療 約3日後、PDT薬剤はがんに集積 光線を腫瘍部位に充てることでPDT薬剤を活性化 がん患者の方にPDT薬剤を静脈注射 可視光?赤外光は深部組織に到達できない PhotofrinR Dissolved in glucose injection and 2mg/kg intravenous. The cancer tissue takes Photofrin four times higher than normal tissue and shows over 48 hours stagnation. In contrast, Photofrin is excreted within 24 hours in all of normal tissue. 48 to 72 hours after injection, the wavelength 6