促甲状腺素和甲状腺素轴对脂质代谢调节的分子机制绪论.doc

作者简介 姓名：赵慧 女 生于1988.05.25 泰山医学院研究生在读，内科学内分泌专业 详细地址：山东省泰安市泰山区迎胜东路2号583865994@ 促甲状腺素和甲状腺激素轴对脂质代谢调节的分子机制 赵慧1，秦树存1，邓仰欣2，宋国华1 （1.泰山医学院动脉粥样硬化研究所，山东泰安 271000；2. 泰山医学院附属医院常见的有甲状腺功能亢进症、甲状腺功能低密度脂蛋白(LDLpoB)明显降低；甲减时主要是TC、LDL和apoB升高。尽管目前TSH与TC、TG、高密度脂蛋白胆固醇(HDL-C)低密度脂蛋白胆固醇(LDL-C)The Molecular Mechanism on the Regulation of Lipid Metabolism by Thyrotropin and Thyroxine Axis. ZHAO Hui1, Qin Shu-Cun1, Song Guo-Hua1, Deng Yang-Xin2 1Atherosclerosis Research Institute of Taishan Medical College, Taian Shandong, 271000, China; 2Affiliated Hospital of Taishan Medical College, Shandong Taian 271000, China ABSTRACT Hyperthyroidism, hypothyroidism, subclinical hyperthyroidism and subclinical hypothyroidism are the most common?thyroid diseases. The synthesis and degradation of?lipids were?in balance when?thyrotropin(TSH) and thyrotropin(TH) axis were in the normal level, so the lipid metabolism?can be maintained in a state of balance. The body blood lipid spectrum will change because of the receptors which involved in lipid metabolism and the activity of enzyme are affected by TSH and TH when something wrong occurs. In general?the blood lipid?was negatively correlated with TH level. Total cholesterol(TC), triglycerides(TG), low density lipoprotein(LDL) and apolipoprotein B(apoB) will be decreased significantly when hyperthyrea occurs. TC,?LDL and?apoB will be increased when hypothyrea occurs. TSH?can influence the?synthesis and?metabolism of lipid?by various ways although the relations between TSH and TC, TG, High density lipoprotein cholesterol(HDL-C) and Low density lipoprotein cholesterol(LDL-C) are different. This paper?is to explore the molecular mechanism on the regulation of lipid metabolism by thyrotropin and thyroxine axis. KEY WORDS Thyrotropin；Thyroxine；Hyperthyroidism；Hypothyroidism；Subclinical hypothyroidism；Lipid metabolism 随着生活节奏的日益加快，人们在工作、学习、生活中要比以前承受更多的诸如紧张的工作、不良人际关系、愤怒、焦虑、恐惧等应激事件的干扰，同时环境污染带来的各种应激源的刺激也可引起不同的应激反应。在多种急性应激下，持续强烈的刺激将导致机