pedpea-15在癌细胞中的表达对癌细胞的影响.docVIP

PED/PEA-15在癌细胞中的表达对癌细胞的影响 糖尿星形胶质细胞富含的磷脂蛋白15（phosphoprotein enriched in diabetes phosphoproteinenriched in astrocytes-15 PED /PEA-15）是一种新近发现的凋亡抑制因子，类似于XIAP、Surivivin 等，由131 个氨基酸组成，其前80 个氨基酸形成规范的“死亡效应区deatheffectordomain，DED）”后51 个氨基酸形成结构不规则的C 末端尾。研究表明，PED ／ PEA-15 可以抑制肿瘤坏死因子（tumor necrosis factor，TNF）凋亡信号途径， 通过其DED 区域作用于衔接蛋白FADD 和天冬氨酸特异性半胱氨酸蛋白酶（caspase），与激活的caspase-8、caspase-10 等信号传导分子结合，从而阻断凋亡过程，抑制肿瘤细胞的凋亡，促进肿瘤的发生发展［］Gaumont Leclerc M F， Mukhopadhyay U K， Goumard S， et al．PEA-15 is inhibited by adenovirus E1A and plays a role in ERKnuclear export and ras-induced senescence ［J］． J Biol Chem，2004，279（45）：46802－46809 CONDORELL I G, VIGLIOTTA G, IAVARONE C , et al .PED/ PEA215 gene cont rols glucose t ransport and is over2ex2pressed in type 2 diabetes mellitus [ J ] . EMBO J , 1998 , 17 (14) : 3858-3866. [ 3 ] GAUMONT2L ECL ERC M F , MU KHOPADHYA Y U K,GOUMARD S , et al . PEA215 is inhibited by adenovirus E1A and plays a role in ERK nuclear export and Ras2induced se2nescence[J ] . J Biol Chem , 2004 , 279 (45) : 46802-46809. [4]Francesca F，[1]Gaumont Leclerc M F， Mukhopadhyay U K， Goumard S， et al．PEA-15 is inhibited by adenovirus E1A and plays a role in ERKnuclear export and ras-induced senescence ［J］． J Biol Chem，2004，279（45）：46802－46809 CONDORELL I G, VIGLIOTTA G, IAVARONE C , et al .PED/ PEA215 gene cont rols glucose t ransport and is over2ex2pressed in type 2 diabetes mellitus [ J ] . EMBO J , 1998 , 17 (14) : 3858-3866. [ 3 ] GAUMONT2L ECL ERC M F , MU KHOPADHYA Y U K,GOUMARD S , et al . PEA215 is inhibited by adenovirus E1A and plays a role in ERK nuclear export and Ras2induced se2nescence[J ] . J Biol Chem , 2004 , 279 (45) : 46802-46809. [4]Francesca F，Pietro F, Giuseppe P, etl ..PED/PEA-15, a multifunctional protein controlling cell survival and glucose metabolism [J]. Am J Physiol Endocrinol Metab. 2009 ,297(3):E592-601. [5]Hao C， Beguinot F， Condorelli G， et al． Induction and intracellularregulation of tumor necrosis factor-related apoptosis-induc