中药治疗胃肠动力障碍性疾病的研究进展.PDFVIP

Drug Evaluation Research 第 38 卷 第 3 期 2015 年 6 月 - 336 - 中药治疗胃肠动力障碍性疾病的研究进展 丁 曼 1，周福军 2，华 洁 2，侯文彬 2* 1．天津中医药大学，天津 300193 2．天津药物研究院有限公司，天津 300193 摘 要：胃肠动力障碍性疾病以其较高的发病率，严重影响人们的身体健康和生活质量。在目前医疗水平下，中药以其副作 用小、选择面广、疗效确切等特点对胃肠动力障碍性疾病的治疗效果明显优于西药。就临床上用于治疗胃肠动力障碍性疾病 常用的中药复方（包括半夏泻心汤、四磨汤、大承气汤等）以及单味中药（包括枳实、槟榔、砂仁等）对胃肠运动的影响进 行综述，为胃肠动力障碍性疾病的临床治疗与新药开发提供依据。 关键词：中药；胃肠动力障碍性疾病；半夏泻心汤；四磨汤；枳实；槟榔 中图分类号：R285 文献标志码：A 文章编号：1674 - 6376 (2015) 03 - 0336 - 05 DOI: 10.7501/j.issn.1674-6376.2015.03.023 Studies progressing of traditional Chinese medicine treatment of gastrointestinal motility disorders DING Man1，ZHOU Fu-jun2，HUA Jie2，HOU Wen-bin2 1.Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China 2.Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China Abstract: Disorders of gastrointestinal motility have high incidence, and it has seriously affected peoples health and the quality of life. In the present medical condition, the traditional Chinese medicine(TCM) has the characteristics of little side effect, a wide range of choice, good curative effect,and therapeutic effect of which in disorders of gastrointestinal motility have an distinct advantage over the Western medicine. The commonly used clinically for the treatment of gastrointestinal motility disorders of Chinese herbal compound (including Banxiaxiexin Decoction, Simo Decoction, Dachengqi Decoction and so on) and single Chinese herb (including Aurantii Fructus Lmmaturus, Arecae Semen, Amomi Fructus and so on) effect on gastrointestinal movement in the review, and provide reliable basis for clinical treatment and the development of new drugs. Key words: traditional Chinese medicine(TCM);disorders of gastrointestinal motility;Banxiaxiexin Decoction;Simo Decoction; Aurantii Fructus Lmmaturus; Arecae Semen 胃肠动力障碍性疾病包括胃肠道功能性消化不 良、功能性便秘、胃食管反流、肠易激综合征等， 临床表现为脘腹胀满或胃肠疼痛、恶心、呕吐、腹 泻等，近年来该病的发生率逐渐增加，尤其多发于 儿童与老年人[1]。临床中有 30%～40%的消化道疾 病患者最终被确诊为胃肠动力障碍性疾病[2]，该病 已严重危害人们的身体健康与生