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Asian Case Reports in Emergency Medicine 亚洲急诊医学病例研究, 2015, 3, 7-12 Published Online May 2015 in Hans. /journal/acrem /10.12677/acrem.2015.32002 7 The Changes of Amplitude of Low-Frequency Fluctuation in the Acute Phase Patients with Concussion Weimin Wang, Zelin Hao*, Jun Cheng, Jianyue Wu, Wusi Qiu, Qizhou Jiang, Guomin Xiao, Yufeng Zang, Jianping Ding Neurosurgery, The Affiliated Hospital of Hangzhou Normal University, Hangzhou Zhejiang Email: *iamhaozelin@126.com Received: Mar. 26th, 2015; accepted: Apr. 12th, 2015; published: Apr. 17th, 2015 Copyright ? 2015 by authors and Hans Publishers Inc. This work is licensed under the Creative Commons Attribution International License (CC BY). /licenses/by/4.0/ Abstract Objective: To investigate the change of amplitude of low-frequency fluctuation (ALFF) in acute phase patients with concussion. Methods: 10 patients with concussion and 10 healthy control subjects were performed at GE MR750 3T by using the methods of blood oxygenation level de- pendent-functional magnetic resonance imaging (BOLD fMRI) and ALFF in this study. Results: Compared with the control subjects, the patients with concussion showed significantly increased ALFF values in limbic lobe, cingulate gyrus, precuneus, left superior temporal gyrus, left middle temporal gyrus and right frontal gyrus. The clinical manifestations of these patients were the changes of cognitive function such as memory, language and emotional responses. Conclusion: The changes of cognitive function on the patients with concussion were associated with the increased ALFF values in the cognitive-related brain areas. Keywords Concussion, Blood Oxygenation Level Dependent-Functional Magnetic Resonance Imaging (BOLD fMRI), Amplitude of Low-Frequency Fluctuation (ALFF) 脑震荡急性期患者功能磁共振低频振幅变化意 义初探 王卫民，郝泽林*，程 军，吴建跃，裘五四，姜启周，肖国民，臧玉峰，丁建平 *通讯作者。 脑震荡急性期患者功能磁共振低频振幅变化意义初探 8 杭州师范大学附属医院神经外科，浙江 杭州 Email: *iamhaozelin@126.com 收稿日期：20