基于双控荧光开关的NOR和OR分子逻辑门.pdf

2009 年第 67 卷 化 学 学 报 Vol. 67, 2009 第 2 期, 157～161 ACTA CHIMICA SINICA No. 2, 157～161 * E-mail: gxlu@lzb.ac.cn; Tel.: 0931-4968178; Fax: 0931-4968178 Received June 4, 2008; revised August 4, 2008; accepted September 1, 2008. 国家自然科学基金(No.资助项目. ·研究论文· 基于双控荧光开关的 NOR 和 OR 分子逻辑门 宗国强 a,b 吕功煊*,a ( a中国科学院兰州化学物理研究所 羰基合成与选择氧化国家重点实验室 兰州 730000) ( b中国科学院研究生院 北京 100049) 摘要 合成了 L-精氨酸蒽衍生物 1, 考察了碱土及过渡金属离子对主体分子 1 荧光光谱的影响, 结果发现, 在中性水溶液条件下只有Cu2＋能有效地猝灭其荧光. 另外, 通过OH－/H＋和Cu2＋/乙二胺四乙酸(EDTA)均能对化合物 1的荧光强度进行可逆性调控. 在此基础上, 我们以化合物1水溶液作为起始状态, 以OH－和Cu2＋为两化学输入, 构建了一个“或非” (NOR)分子逻辑门; 以 1-Cu2＋水溶液体系作为起始状态, 以 H＋和 EDTA 为两化学输入, 构建了一个“或”(OR)分子逻辑门. 关键词 分子逻辑门; 荧光开关; L-精氨酸; 蒽; Cu2＋ NOR and OR Molecular Logic Gates Based on Double-control Fluorescent Switch Zong, Guoqiang a,b Lü, Gongxuan* ,a ( a State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000) ( b Graduate University of Chinese Academy of Sciences, Beijing 100049) Abstract An L-arginine derivative featuring an anthracene unit (1) was synthesized, which could selec- tively bind Cu 2＋ in neutral aqueous solutions resulting in fluorescence quenching. Almost no fluorescent changes were observed upon the addition of other metal ions such as Mg 2＋ , Co 2＋ , Ba 2＋ , Ca 2＋ , Ni 2＋ , Zn 2＋ , Cd 2＋ , Fe 3＋ and Hg 2＋ . In addition, the fluorescence intensity of 1 could be reversibly tuned by OH － /H ＋ or Cu 2＋ /ethylenediaminetetraacetic acid (EDTA) in the neutral aqueous solutions. Hereby, starting with com- pound 1 system, a NOR logic gate was fabricated with OH － and Cu 2＋ as two chemical inputs. On the other hand, starting with 1-Cu 2＋ complex system, an OR logic gate was fabricated with H ＋ and EDTA as two chemical inputs. Keywords molecular logic gate; fluorescent switch; L-arginine; anthracene; Cu 2＋ 分子器件因在材料科学领域具有独特的优势和广阔的应用前景而引起人们的广泛重视, 被普遍认为是最有希望代替传统的以硅为基础的器件材料, 已经成为 21 世纪科学研究的重点之一. 随着科技进步的日新月异, 具有各种功能的分子器件不