Early peak of hydrogen during lactose.pdf

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Early peak of hydrogen during lactose

Open Journal of Gastroenterology, 2014, 4, 40-44 OJGas /10.4236/ojgas.2014.41007 Published Online January 2014 (/journal/ojgas/) Early peak of hydrogen during lactose breath test predicts intestinal motility Veronica Ojetti1, Teresa Antonella Di Rienzo1, Giovanna D’Angelo1, Emidio Scarpellini1, Gianluca Rizzo2, Maria Chiara Campanale1, Valentina Cesario1, Antonio Gasbarrini1 1Department of Internal Medicine, Catholic University, Rome, Italy 2Department of Surgery, Catholic University, Rome, Italy Email: veronica.ojetti@tin.it Received 6 December 2013; revised 6 January 2014; accepted 18 January 2014 Copyright ? 2014 Veronica Ojetti et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. In accor- dance of the Creative Commons Attribution License all Copyrights ? 2014 are reserved for SCIRP and the owner of the intellectual property Veronica Ojetti et al. All Copyright ? 2014 are guarded by law and by SCIRP as a guardian. ABSTRACT Lactose breath test (LBT) is considered the gold standard for the diagnosis of lactose malabsorption. The test is considered positive for a peak of hydrogen (H2) ≥ 20 parts per million (ppm) above the baseline. Some patients (pts) showed a rapid peak between 30 and 90 minutes after lactose ingestion. The aim of this study was to evaluate the predictive value of an early peak during a LBT and an accelerated oro-cecal transit time (OCTT). We retrospectively analyzed all pts who referred to our Gastroenterology unit for Irritable Bowel Syndrome, from January to Septem- ber 2012, who performed LBT, glucose and lactulose breath test. We consider a positive LBT for a peak of H2 20 ppm, a positive GHBT for a peak 12 ppm and we considered a normal OCCT a peak of H2 ≥ 10 ppm between 75 ± 105 m

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