Effects of Mobile Phone Radiation on Reproduction and Development in Drosophila melanogaster.pdf

Effects of Mobile Phone Radiation on Reproduction and Development in Drosophila melanogaster.pdf

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Effects of Mobile Phone Radiation on Reproduction and Development in Drosophila melanogaster

Journal of Cellular Biochemistry 89:48–55 (2003) Effects of Mobile Phone Radiation on Reproduction and Development in Drosophila melanogaster David Weisbrot,1 Hana Lin,2 Lin Ye,1 Martin Blank,3 and Reba Goodman1* 1Department of Pathology, Columbia University Health Sciences, 630 West 168 St. NYC, New York 10032 2Department of Anatomy, Columbia University Health Sciences, 630 West 168 St. NYC, New York 10032 3Department of Physiology, Columbia University Health Sciences, 630West 168 St. NYC, New York 10032 Abstract In this report we examined the effects of a discontinuous radio frequency (RF) signal produced by a GSM multiband mobile phone (900/1,900 MHz; SAR 1.4 W/kg) on Drosophila melanogaster, during the 10-day developmental period from egg laying through pupation. As found earlier with low frequency exposures, the non-thermal radiation from the GSM mobile phone increased numbers of offspring, elevated hsp70 levels, increased serum response element (SRE) DNA-binding and induced the phosphorylation of the nuclear transcription factor, ELK-1. The rapid induction of hsp70 within minutes, by a non-thermal stress, together with identified components of signal transduction pathways, provide sensitive and reliable biomarkers that could serve as the basis for realistic mobile phone safety guidelines. J. Cell. Biochem. 89: 48–55, 2003.  2003 Wiley-Liss, Inc. Key words: mobile phone radiation; hsp70; heat shock protein; HSP70 promoter; DNA; electron transfer; MAPK cascades Stressproteins (hsps) are inducedbyavariety of potentially harmful extracellular stimuli, such as changes in pH, heavy metals, and sud- den temperature increase. The role of these pro- teins is to maintain the structure and function of cellular proteins. Hsp70 is also induced in cells and tissues by non-thermal, extremely low frequency (ELF) electromagnetic (EM) fields ( 3,000 Hz) [Goodman and Henderson, 1988; Goodman et al., 1994; Goodman and Blank, 1998]. The induction of increased levels of hsp70 is

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