Functional connectivity mapping of the human precuneus by resting state fMRI.pdf

下载文档

10
0
约8.81万字
约 15页
2017-04-06 发布于江苏
举报
版权申诉
保障服务

Functional connectivity mapping of the human precuneus by resting state fMRI.pdf

1、本文档共15页，可阅读全部内容。
2、有哪些信誉好的足球投注网站（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。
3、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。

Functional connectivity mapping of the human precuneus by resting state fMRI

NeuroImage 59 (2012) 3548–3562 Contents lists available at SciVerse ScienceDirect NeuroImage j ourna l homepage: www.e lsev ie r .com/ locate /yn imgFunctional connectivity mapping of the human precuneus by resting state fMRI Sheng Zhang a,?, Chiang-shan R. Li a,b,c a Department of Psychiatry, Yale University, New Haven, CT 06519, United States b Department of Neurobiology, Yale University, New Haven, CT 06520, United States c Interdepartmental Neuroscience Program, Yale University, New Haven, CT 06520, United States? Corresponding author at: Connecticut Mental Healt New Haven CT 06519, United States. Fax: +1 203 974 7 E-mail address: sheng.zhang@ (S. Zhang). 1053-8119/$ – see front matter ? 2011 Elsevier Inc. All doi:10.1016/j.neuroimage.2011.11.023a b s t r a c ta r t i c l e i n f oArticle history: Received 12 May 2011 Revised 2 November 2011 Accepted 4 November 2011 Available online 12 November 2011 Keywords: Functional connectivity fMRI Resting state Precuneus Default networkPrecuneus responds to a wide range of cognitive processes. Here, we examined how the patterns of resting state connectivity may define functional subregions in the precuneus. Using a K-means algorithm to cluster the whole-brain “correlograms” of the precuneus in 225 adult individuals, we corroborated the dorsal- anterior, dorsal-posterior, and ventral subregions, each involved in spatially guided behaviors, mental imagery, and episodic memory as well as self-related processing, with the ventral precuneus being part of the default mode network, as described extensively in earlierwork. Furthermore,we showed that the lateral/medial volumes of dorsal anterior and dorsal posterior precuneus are each connectedwith areas ofmotor execution/attention and motor/visual imagery, respectively. Compared to the ventral precuneus, the dorsal precuneus showed greater connectivity with occipital and posterior parietal cortices, but less connectivity with the medial superior frontal and orbitofrontal gyri, an