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Gastroparesis
ORIGINAL ARTICLE
Small Intestinal Bacterial Overgrowth in Gastroparesis
Nina S. George ? Abhinav Sankineni ?
Henry P. Parkman
Received: 13 May 2012 / Accepted: 19 September 2012
Springer Science+Business Media New York 2012
Abstract
Objective To determine symptoms of small intestinal
bacterial overgrowth (SIBO) in gastroparesis patients.
Methods Patients undergoing LBT (lactulose breath test)
for evaluation of SIBO were included. LBT was considered
positive on the basis of three conventional criteria: (1)
hydrogen level increase [20 ppm above baseline by
90 min (H2@90min); (2) dual hydrogen peaks ([10 ppm
increase over baseline before second peak [20 ppm
(DPHBT); and (3) breath methane increase of[20 ppm above
baseline by 90 min. Results of gastric emptying scintigra-
phy (GES) were recorded. Patients completed the Patient
Assessment of Upper Gastrointestinal Disorders-Symptom
Severity Index.
Results Of 740 patients who underwent LBT from
December 2009 to August 2011, 471 underwent GES, with
201 having delayed GES. Of patients with delayed GES
who underwent LBT 87 % were female, 23 % diabetic,
49 % used gastric acid suppressants, 29 % used opiate
analgesics, 35 % used pro-motility medications, and 27 %
had a history of gastrointestinal surgery. Overall, 79 (39 %)
patients with gastroparesis had evidence of SIBO by LBT:
30 (15 %) had positive H2@90min, 53 (26 %) positive
DPHBT, and 6 (3 %) positive breath methane test. In
gastroparesis patients with positive H2@90min, there was
increased severity of bloating (3.80 ± 0.20 vs 3.29 ± 0.12;
P = 0.02), early satiety (3.57 ± 0.27 vs 3.05 ± 0.13;
P = 0.045), and postprandial fullness (4.20 ± 0.18 vs
3.52 ± 0.12; P \ 0.01) compared with negative H2@90
min patients. No significant difference in symptom severity
was seen between positive and negative DPHBT gastro-
paresis patients.
Conclusion In our cohort, 39 % of gastroparesis patients
tested positive for SIBO by LBT. Positive H2@90min
testing by LBT was associated with in
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