How to Interpret Hydrogen Breath Tests.pdf

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How to Interpret Hydrogen Breath Tests

JNM Journal of Neurogastroenterology and Motility How to Interpret a Functional or Motility Test 312 J Neurogastroenterol Motil, Vol. 17 No. 3 July, 2011 DOI: 10.5056/jnm.2012 ? 2011 The Korean Society of Neurogastroenterology and Motility J Neurogastroenterol Motil, Vol. 17 No. 3 July, 2011 How to Interpret Hydrogen Breath Tests Uday C Ghoshal Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India ? Hydrogen breath tests using various substrates like glucose, lactulose, lactose and fructose are being used more and more to diagnose small intestinal bacterial overgrowth (SIBO) and lactose or fructose malabsorption. Though quantitative culture of je- junal aspirate is considered as gold standard for the diagnosis of SIBO, hydrogen breath tests, in spite of their low sensitivity, are popular for their non-invasiveness. Glucose hydrogen breath test is more acceptable for the diagnosis of SIBO as conven- tionally accepted double-peak criterion on lactulose hydrogen breath test is very insensitive and recently described early-peak criterion is often false positive. Hydrogen breath test is useful to diagnose various types of sugar malabsorption. Technique and interpretation of different hydrogen breath tests are outlined in this review. (J Neurogastroenterol Motil 2011;17:312-317) Key Words Breath tests; Hydrogen; Intestine, small; Irritable bowel syndrome Received: June 7, 2011 Revised: June 19, 2011 Accepted: June 20, 2011 CC This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons. org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. *Correspondence: Uday C Ghoshal, MD, DNB, DM, FACG Additional Professor, Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226014, I

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