Methane as indicate.pdf

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Methane as indicate

original article Gut and Liver, Vol. 2, No. 3, December 2008, pp. 180-185 Correspondence to: Krzysztof Jonderko Department of Basic Biomedical Science, School of Pharmacy, Medical University of Silesia, 3, Kasztanowa street, PL-41-205 Sosnowiec, Poland Tel: +48-32-2919272, Fax: +48-32-2945548, E-mail: kjonderko@sum.edu.pl Received on April 15, 2008. Accepted on September 5, 2008. Unreliability of Breath Methane as a Candidate Indicator of Functional Bowel Disorders Krzysztof Jonderko, Agata Gabriel-Ja?niok, Ma?gorzata Szymszal, Anna Kasicka-Jonderko, and Barbara B?ońska-Fajfrowska Department of Basic Biomedical Science, School of Pharmacy, Medical University of Silesia, Sosnowiec, Poland Background/Aims: The aim of this study was to ex- amine the reproducibility of methane and hydrogen in exhaled air breath after a per-oral load of lactulose. Methods: Methane was present in the exhaled breath of 21 of 50 healthy subjects recruited by advertise- ment. Three methane breath tests were performed in 12 women (aged 23.6±0.5 years, mean±SEM) after they consumed 10 g of lactulose dissolved in 300 ml of water. Short- and medium-term reproducibilities were assessed by paired examinations taken 3 and 17 days (median) apart, respectively. Results: High values of coefficients of variation for paired examina- tions (CVp) indicated a poor short-term reproducibility of parameters characterizing either the methane or hy- drogen excretion in breath air: CVp values of the maximum net increments over baseline in methane (max CH4_net), and in hydrogen (max H2_net), were 34% and 41%, respectively. Moreover, the reproduci- bility consistently deteriorated with increasing time gap between repeat measurements (CVp: 60% for max CH4_net and 64% for max H2_net). Conclusions: The low reproducibility of parameters characterizing quanti- tative methane breath excretion suggests that caution is necessary when judging the clinical usefulness of the methane breath test after a p

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